PubMed 28877763

We found that tau phosphorylation at Y18 is significantly increased in neurons that are also immunopositive for pSyk (Fig. 10d, p < 0.05) which is consistent with previous data showing that in vitro Syk can phosphorylates tau at Y18.

BEL
p(HGNC:MAPT, pmod(Ph, Tyr, 18)) positiveCorrelation p(HGNC:SYK)
Hash
1dbf0efbd9
MeSHAnatomy
Neurons
Networks
BEL
p(HGNC:SYK) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Tyr, 18))
Hash
38e4902855
MeSHAnatomy
Neurons
Networks
BEL
act(p(HGNC:SYK), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Tyr, 18))
Hash
917efafbba
Networks

PubMed 28877763

Altogether, these data suggest that only certain pathogenic forms of tau (MC1, Y18) promote Syk activation, whereas Syk activation appears to directly in- duce tau phosphorylation at Y18 and to indirectly regulate tau phosphorylation at multiple epitopes (S396/404, S202) as well as tau misfolding (MC1, TOC1).

BEL
p(HGNC:MAPT, pmod(Ph, Tyr, 18)) increases act(p(HGNC:SYK))
Hash
38fc59b21e
Networks
BEL
act(p(HGNC:SYK)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Tyr, 18))
Hash
456481bb87
Networks

PubMed 28877763

We found an increase in Syk activation in DNs surrounding A β deposits as well as in neurons displaying an accumu- lation of phosphorylated Tau at Y18 and elevated levels of MC1 pathogenic tau conformers in AD brain sections whereas only weak immunoreactivity for pSyk was ob- served in brain sections from a non-demented control (Figs. 15, 16 and 17).

BEL
p(HGNC:MAPT, pmod(Ph, Tyr, 18)) positiveCorrelation act(p(HGNC:SYK))
Hash
695a07776a
CellStructure
Neurites
MeSHAnatomy
Brain
MeSHDisease
Alzheimer Disease
Networks
BEL
act(p(HGNC:SYK)) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Tyr, 18))
Hash
4490de3796
CellStructure
Neurites
MeSHAnatomy
Brain
MeSHDisease
Alzheimer Disease
Networks

PubMed 25331948

Syk has been shown to mediate the phosphorylation of Tau at Tyr-18 (56).

PubMed 28877763

Interestingly, Syk up- regulation in SH-SY5Y cells leads to a significant in- crease (1.7-fold) in phosphorylated tau at Y18 (Fig. 14c, p < 0.01) and at S396/404 (Fig. 14d, 3-fold, p < 0.0001) compared to control cells.

BEL
p(HGNC:SYK) increases p(HGNC:MAPT, pmod(Ph, Tyr, 18))
Hash
7173300b2e
Networks

PubMed 26631930

In addition, tau can be phosphorylated by tyrosine kinases such as the SRC family members LCK, SYK and FYN at Tyr18, and the ABL family members ARG and ABL1 at Tyr394 (REF. 45).

BEL
p(HGNC:SYK) directlyIncreases p(HGNC:MAPT, pmod(Ph, Tyr, 18))
Hash
528eb9be73
Networks

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.