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Appears in Networks 1

In-Edges 2

a(CHEBI:ATP) regulates complex(p(HGNC:HSPD1), p(HGNC:HSPE1)) View Subject | View Object

GroEL and GroES undergo a complex binding-and-release cycle that is allosterically regulated by ATP binding and hydrolysis in the GroEL subunits (Figure 6b) (4, 77, 100, 136). PubMed:23746257

complex(a(CHEBI:ATP), p(HGNC:HSPD1)) increases complex(p(HGNC:HSPD1), p(HGNC:HSPE1)) View Subject | View Object

Cooperative binding of ATP to GroEL initiates a series of conformational changes that trigger the association of GroES, followed by substrate release from hydrophobic binding sites into a GroES-capped, hydrophilic folding chamber (137). PubMed:23746257

Out-Edges 3

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BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.