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Tau oligomers and tau toxicity in neurodegenerative disease v1.0.0

Tau oligomers and tau toxicity in neurodegenerative disease by Ward et al., 2012

In-Edges 3

p(HGNC:MAPT) decreases complex(a(GO:microtubule), a(MESH:Dyneins)) View Subject | View Object

Tau reportedly exerts an effect on axonal transport by interfering and reducing the attachment frequency of the motor proteins to the microtubules [28] PubMed:22817713

complex(a(GO:microtubule), p(HGNC:DCTN1)) increases complex(a(GO:microtubule), a(MESH:Dyneins)) View Subject | View Object

Fifth, tau may bind to the p150 subunit of dynactin and thereby facilitate the association of dynactin with microtubules, which stabilizes the interaction of dynein with microtubules and thus supports transport by dynein PubMed:26631930

p(HGNC:MAPT) decreases complex(a(GO:microtubule), a(MESH:Dyneins)) View Subject | View Object

First, tau competes with kinesin or dynein motors for binding to microtubules, reducing the binding frequency, motile fraction and run length of kinesin and dynein (without changing the motor velocity of kinesin and dynein), and thereby slowing down both anterograde and retrograde transport PubMed:26631930

Out-Edges 2

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.