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p(HGNC:SOD1, var("p.Ala4Val"))

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
SOD1
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 1

Protein aggregation can inhibit clathrin-mediated endocytosis by chaperone competition v1.0.0

In-Edges 1

p(HGNC:SOD1) hasVariant p(HGNC:SOD1, var("p.Ala4Val")) View Subject | View Object

Appears in Networks:

Out-Edges 1

p(HGNC:SOD1, var("p.Ala4Val")) decreases bp(GO:"clathrin-dependent endocytosis") View Subject | View Object

Down- regulation of CME was not limited to polyQ-induced aggre- gation; cells with aggregated mutant SOD1 A4V also exhibited a 50 ± 10% decrease in levels of internalized transferrin com- pared with cells expressing the soluble WT or mutant protein (Fig. 1 E–G ). PubMed:24706768

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About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.