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a(CHEBI:oxyhemoglobin)

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Entity

Name
oxyhemoglobin
Namespace
chebi
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/chebi-names.belns

Appears in Networks 1

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 4

a(HM:"nitrite oxidation") positiveCorrelation a(CHEBI:oxyhemoglobin) View Subject | View Object

Figures 5C-5D show that d7 propagation rates for nitrite oxidation correlate with both d7 and d35 cell-free oxyhemoglobin. PubMed:26202471

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a(HM:"stored erythrocytes") positiveCorrelation a(CHEBI:oxyhemoglobin) View Subject | View Object

Figures 2A-F show changes in oxyhemoglobin, methemoglobin and free heme in both the intraerythrocytic and supernatant fractions in both d7 and d35 RBC. Significant storage-dependent increases for all species in the cell-free fraction were observed, with no storage-dependent differences observed in the erythrocyte. PubMed:26202471

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a(HM:"stored erythrocytes") positiveCorrelation a(CHEBI:oxyhemoglobin) View Subject | View Object

Consistent with our previous studies [25,36], free oxyHb, metHb, and heme levels were increased after 14 d of RBC storage, being 930 ± 125 μM, 40.3 ± 8.8 μM, and 168 ± 44.7 μM, respectively (mean ± SEM, n = 7). PubMed:29522519

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rxn(reactants(a(CHEBI:"nitric oxide"), a(CHEBI:oxyhemoglobin)), products(a(CHEBI:methemoglobin), a(CHEBI:nitrate))) hasReactant a(CHEBI:oxyhemoglobin) View Subject | View Object

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Out-Edges 5

a(CHEBI:oxyhemoglobin) increases a(CHEBI:methemoglobin) View Subject | View Object

For example, autooxidation of oxyhemoglobin (HbO2) or oxymyoglobin (MbO2) produces met-Hb or met-Mb, respectively, and superoxide radicals (O2•−, HO2•) via electron transfer [3,4]. PubMed:24486321

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Introduction

a(CHEBI:oxyhemoglobin) positiveCorrelation a(HM:"stored erythrocytes") View Subject | View Object

Figures 2A-F show changes in oxyhemoglobin, methemoglobin and free heme in both the intraerythrocytic and supernatant fractions in both d7 and d35 RBC. Significant storage-dependent increases for all species in the cell-free fraction were observed, with no storage-dependent differences observed in the erythrocyte. PubMed:26202471

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Text Location
Results

a(CHEBI:oxyhemoglobin) positiveCorrelation a(HM:"stored erythrocytes") View Subject | View Object

Consistent with our previous studies [25,36], free oxyHb, metHb, and heme levels were increased after 14 d of RBC storage, being 930 ± 125 μM, 40.3 ± 8.8 μM, and 168 ± 44.7 μM, respectively (mean ± SEM, n = 7). PubMed:29522519

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Text Location
Results

a(CHEBI:oxyhemoglobin) positiveCorrelation a(HM:"nitrite oxidation") View Subject | View Object

Figures 5C-5D show that d7 propagation rates for nitrite oxidation correlate with both d7 and d35 cell-free oxyhemoglobin. PubMed:26202471

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Text Location
Results

a(CHEBI:oxyhemoglobin) causesNoChange a(CHEBI:"adenosine triphosphate") View Subject | View Object

In contrast, less ATP depletion was observed during exposure to heme-albumin, and no effect could be detected when either cell type was exposed to metHb or oxyHb at concentrations of up to 500 lmolL1, even in the absence of serum. PubMed:29610666

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Cell Ontology (CL)
neutrophil
MeSH
Human Umbilical Vein Endothelial Cells
Text Location
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About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.