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p(MGI:Otub1, var("p.Cys91Ala"))

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Entity

Name
Otub1
Namespace
mgi
Namespace Version
20181021
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/f2f993e599694ab5ce989cc39d789a499f75db99/external/mgi-names.belns

Appears in Networks 1

Tau interactome mapping based identification of Otub1 as Tau deubiquitinase involved in accumulation of pathological Tau forms in vitro and in vivo v1.0.0

In-Edges 1

p(MGI:Otub1) hasVariant p(MGI:Otub1, var("p.Cys91Ala")) View Subject | View Object

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Out-Edges 2

p(MGI:Otub1, var("p.Cys91Ala")) causesNoChange p(MGI:Mapt, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) View Subject | View Object

Immunostaining and biochemical analysis, 2 months postinjection, unambiguously revealed that the catalytically dead mutant C91A did not affect AT8-stained Tau in vivo, while N-terminal truncated mutant of Otub1 increased AT8-positive Tau in vivo, similarly as wild-type Otub1 (Fig. 8). PubMed:28083634

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p(MGI:Otub1, var("p.Cys91Ala")) causesNoChange a(HBP:"Tau oligomers") View Subject | View Object

This revealed significantly increased oligomeric Tau forms, following expression of wild-type Otub1, but not following expression of GFP or of the catalytically inactive form of Otub1 (C91A) (Fig. 8c). PubMed:28083634

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.