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p(HGNC:MAP1LC3B)

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Entity

Name
MAP1LC3B
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 4

Tau Biochemistry v1.2.5

Tau Biochemistry Section of NESTOR

Alzheimer’s disease and the autophagic-lysosomal system v1.0.0

The Ubiquitin–Proteasome System and the Autophagic–Lysosomal System in Alzheimer Disease v1.0.0

Autophagy and the ubiquitin-proteasome system: collaborators in neuroprotection v1.0.0

In-Edges 6

p(HGNC:PICALM) negativeCorrelation p(HGNC:MAP1LC3B) View Subject | View Object

A highly significant correlation was found between decreased levels of PICALM and increased levels of LC3-II (p=0.0032) or decreased levels of Beclin-1 (p=0.0295) in the total brain lysates from these diseases (Fig 6D,E). PubMed:27260836

Appears in Networks:
Annotations
Disease Ontology (DO)
Alzheimer's disease
Disease Ontology (DO)
Down syndrome
Disease Ontology (DO)
Pick's disease
Disease Ontology (DO)
progressive supranuclear palsy

a(CHEBI:"methylene blue") increases p(HGNC:MAP1LC3B) View Subject | View Object

Methylene blue, a contrast agent that can reduce tau misfolding, has also been shown to induce macroautophagy, as indicated by elevated Beclin 1 and LC3-II levels and reduced tau and p62 levels in organotypic neuronal cultures and a mouse model of FTD [159] PubMed:29758300

Appears in Networks:

bp(GO:"lysosomal protein catabolic process") decreases p(HGNC:MAP1LC3B) View Subject | View Object

In APP transgenic mouse models of AD, undigested autophagy substrates including LC3-II, p62, and ubiquitinated proteins accumulate in neuronal AVs, establishing that autophagic protein turnover in lysosomes is impeded (Yang et al. 2011). PubMed:22908190

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

complex(a(CHEBI:phosphatidylethanolamine), a(GO:phagophore), p(HGNC:MAP1LC3B)) hasComponent p(HGNC:MAP1LC3B) View Subject | View Object

Appears in Networks:

complex(a(CHEBI:phosphatidylethanolamine), p(HGNC:MAP1LC3B)) hasComponent p(HGNC:MAP1LC3B) View Subject | View Object

Appears in Networks:

complex(a(GO:autophagosome), p(HGNC:MAP1LC3B)) hasComponent p(HGNC:MAP1LC3B) View Subject | View Object

Appears in Networks:

Out-Edges 3

p(HGNC:MAP1LC3B) negativeCorrelation p(HGNC:PICALM) View Subject | View Object

A highly significant correlation was found between decreased levels of PICALM and increased levels of LC3-II (p=0.0032) or decreased levels of Beclin-1 (p=0.0295) in the total brain lysates from these diseases (Fig 6D,E). PubMed:27260836

Appears in Networks:
Annotations
Disease Ontology (DO)
Alzheimer's disease
Disease Ontology (DO)
Down syndrome
Disease Ontology (DO)
Pick's disease
Disease Ontology (DO)
progressive supranuclear palsy

p(HGNC:MAP1LC3B) increases complex(a(CHEBI:phosphatidylethanolamine), p(HGNC:MAP1LC3B)) View Subject | View Object

LC3-I becomes conjugated to PE to form “LC3-II” and thereby covalently associates with the phagophore PubMed:18930136

Appears in Networks:

p(HGNC:MAP1LC3B) increases complex(a(GO:autophagosome), p(HGNC:MAP1LC3B)) View Subject | View Object

While GABARAP and GATE-16 may also be conjugated to PE in experimental systems, at present MAP-LC3 (typically abbreviated LC3) is the only protein that is known to remain associated with the autophagosome in higher eukaryotes. PubMed:18930136

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.