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complex(a(GO:"proteasome complex"), p(HGNC:USP14))

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Perilous journey: a tour of the ubiquitin–proteasome system v1.0.0

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complex(a(GO:"proteasome complex"), p(HGNC:USP14)) hasComponent a(GO:"proteasome complex") View Subject | View Object

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complex(a(GO:"proteasome complex"), p(HGNC:USP14)) hasComponent p(HGNC:USP14) View Subject | View Object

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complex(a(GO:"proteasome complex"), p(HGNC:USP14)) increases bp(GO:"protein catabolic process") View Subject | View Object

It was initially believed that the presence of DUBs at the proteasome (such as Uch37/UchL5 and Usp14) would promote the degradation of proteins through facilitating substrate processing (see also the next section) PubMed:24457024

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complex(a(GO:"proteasome complex"), p(HGNC:USP14)) decreases bp(GO:"protein catabolic process") View Subject | View Object

However, recent studies have shown that, by contrast, upon chemical inhibition of the proteasome-bound DUB Usp14, the degradation of aggregation-prone substrates in mammalian tissue culture cells significantly increased [65] PubMed:24457024

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BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.