path(HM:"vaso-occlusive crisis")
CO also inhibited stasis in mice treated with SnPP + Hb without Hp or Hpx. PubMed:29694434
For example, one of the severe complications of sickle-cell disease is vaso-occlusion, an outcome that can be triggered in mice upon heme administration [27,32]. PubMed:26875449
Heme is one of the factors capable of inducing stimulation and damage of endothelium, promoting the recruitment of neutrophils and sickle-cell erythro- cytes, and subsequently prompting a vaso-occlusive crisis. PubMed:26875449
Heme may be implicated and contribute to the development of (i) bp(MESH: PubMed:26875449
The released heme can activate the innate immune pattern recognition receptor toll-like receptor 4 (TLR4) on inflammatory cells, platelets and endothelium, promoting a pro-inflammatory and pro-coagulant phenotype, ultimately leading to vaso-occlusion, ischemia-reperfusion physiology, tissue injury, and pain in murine models of SCD [5, 7±10]. PubMed:29694434
Administration of heme in healthy volunteers caused thrombophlebitis, demonstrating that it can cause vascular inflammation followed by vascular obstruction [18]. PubMed:29929138
Heme/TLR-4 signaling, moreover, was found to activate NF-κB and trigger vaso-occlusion [42]. PubMed:29956069
The circulating MPs can internalize free heme and transfer it to vascular endothelium, promoting vaso-occlusion, or amplify systemic inflammation via thrombin mediated activation of the complement system [57]. PubMed:28458720
Infusion of exogenous hemoglobin into SS-mice can markedly increase stasis compared to the amount of spontaneous stasis [5]. PubMed:29694434
These findings are consistent with a recent study which showed that both Hp and hemopexin (heme scavenger) were equally effective in preventing vasoocclusion in a sickle cell mouse model infused with Hb [73]. PubMed:24486321
Thus a single infusion of Hp or Hpx inhibited stasis for 48h. PubMed:29694434
Sickle mice co-infused with Hb + Hp, Hb + Hpx or Hb + Hp + Hpx had less stasis 1h after infusion than mice infused with Hb + albumin or Hb (Fig 1B). PubMed:29694434
Hp and Hpx significantly inhibited stasis in response H/R or LPS (Fig 5). PubMed:29694434
These findings are consistent with a recent study which showed that both Hp and hemopexin (heme scavenger) were equally effective in preventing vasoocclusion in a sickle cell mouse model infused with Hb [73]. PubMed:24486321
Likewise, 395 infusion of haptoglobin or hemopexin in HbS mice inhibited hemoglobin-dependent 396 vaso-occlusion (3). PubMed:28314763
Thus a single infusion of Hp or Hpx inhibited stasis for 48h. PubMed:29694434
Sickle mice co-infused with Hb + Hp, Hb + Hpx or Hb + Hp + Hpx had less stasis 1h after infusion than mice infused with Hb + albumin or Hb (Fig 1B). PubMed:29694434
Hp and Hpx significantly inhibited stasis in response H/R or LPS (Fig 5). PubMed:29694434
We have previously shown that induction of HO-1 expression or liver-directed HO-1 gene therapy inhibits stasis in sickle mice exposed to H/R [38, 45]. PubMed:29694434
Vaso-occlusion of the lung microvasculature may result in the development of the ACS through the infarction of the lung parenchyma. PubMed:24904418
Depending on the extension of the vaso-occlusion, some tissues may experience hypoxia and damage. PubMed:24904418
Hp and Hpx significantly inhibited stasis in response H/R or LPS (Fig 5). PubMed:29694434
Depending on the extension of the vaso-occlusion, some tissues may experience hypoxia and damage. PubMed:24904418
Hp and Hpx significantly inhibited stasis in response H/R or LPS (Fig 5). PubMed:29694434
Vaso-occlusion of the lung microvasculature may result in the development of the ACS through the infarction of the lung parenchyma. PubMed:24904418
The released heme can activate the innate immune pattern recognition receptor toll-like receptor 4 (TLR4) on inflammatory cells, platelets and endothelium, promoting a pro-inflammatory and pro-coagulant phenotype, ultimately leading to vaso-occlusion, ischemia-reperfusion physiology, tissue injury, and pain in murine models of SCD [5, 7±10]. PubMed:29694434
Thus a single infusion of Hp or Hpx inhibited stasis for 48h. PubMed:29694434
Sickle mice co-infused with Hb + Hp, Hb + Hpx or Hb + Hp + Hpx had less stasis 1h after infusion than mice infused with Hb + albumin or Hb (Fig 1B). PubMed:29694434
Hp and Hpx significantly inhibited stasis in response H/R or LPS (Fig 5). PubMed:29694434
Thus a single infusion of Hp or Hpx inhibited stasis for 48h. PubMed:29694434
Sickle mice co-infused with Hb + Hp, Hb + Hpx or Hb + Hp + Hpx had less stasis 1h after infusion than mice infused with Hb + albumin or Hb (Fig 1B). PubMed:29694434
Hp and Hpx significantly inhibited stasis in response H/R or LPS (Fig 5). PubMed:29694434
Infusion of exogenous hemoglobin into SS-mice can markedly increase stasis compared to the amount of spontaneous stasis [5]. PubMed:29694434
We have previously shown that induction of HO-1 expression or liver-directed HO-1 gene therapy inhibits stasis in sickle mice exposed to H/R [38, 45]. PubMed:29694434
CO also inhibited stasis in mice treated with SnPP + Hb without Hp or Hpx. PubMed:29694434
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