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complex(a(CHEBI:allopurinol), a(CHEBI:heme))

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Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

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Out-Edges 3

complex(a(CHEBI:allopurinol), a(CHEBI:heme)) hasComponent a(CHEBI:allopurinol) View Subject | View Object

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complex(a(CHEBI:allopurinol), a(CHEBI:heme)) hasComponent a(CHEBI:heme) View Subject | View Object

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complex(a(CHEBI:allopurinol), a(CHEBI:heme)) decreases p(MGI:Slc40a1) View Subject | View Object

We showed that cotreatment of macrophages with heme and apocynin (Fig. 7E), as well as with heme and allopurinol (Fig. 7F), fully prevented ferroportin induction by heme. These data revealed that inhibiting superoxide at its production site is an effective way to counteract heme-mediated ferroportin induction. PubMed:29212341

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macrophage
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BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.