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bp(GO:"cellular homeostasis")

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Entity

Name
cellular homeostasis
Namespace
go
Namespace Version
20180921
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/go-names.belns

Appears in Networks 3

Perilous journey: a tour of the ubiquitin–proteasome system v1.0.0

Autophagy and the ubiquitin-proteasome system: collaborators in neuroprotection v1.0.0

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 5

act(a(MESH:Ubiquitin)) regulates bp(GO:"cellular homeostasis") View Subject | View Object

This function is crucial for cellular homeostasis because failure to activate ubiquitin, as seen by the chemical inhibition of E1 activity in the cell, results in the almost immediate shutdown of the entire UPS PubMed:24457024

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bp(GO:"cellular protein catabolic process") regulates bp(GO:"cellular homeostasis") View Subject | View Object

Considering the importance of protein catabolism in maintaining cell homeostasis, it is not surprising that dysregulation of protein turnover is associated with myriad disease states such as cancer and neurodegeneration [5]. PubMed:18930136

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a(CHEBI:heme) negativeCorrelation bp(GO:"cellular homeostasis") View Subject | View Object

These data, in addition to older biochemical studies that empirically used heme to inhibit proteasome function in biochemical assays, led us to the hypothesis that excessive intracellular heme could disrupt cellular protein homeostasis by an inhibitory action on the proteasome. PubMed:25301065

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a(CHEBI:heme) negativeCorrelation bp(GO:"cellular homeostasis") View Subject | View Object

The proteasome is the principal pathway to remove senescent and damaged proteins, and intact proteasome function is essential to preserve and repair cellular homeostasis during oxidative stress, such as that triggered by heme exposure.27 PubMed:25301065

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act(p(PFAM:Proteasome)) positiveCorrelation bp(GO:"cellular homeostasis") View Subject | View Object

The proteasome is the principal pathway to remove senescent and damaged proteins, and intact proteasome function is essential to preserve and repair cellular homeostasis during oxidative stress, such as that triggered by heme exposure.27 PubMed:25301065

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Out-Edges 3

bp(GO:"cellular homeostasis") negativeCorrelation a(CHEBI:heme) View Subject | View Object

These data, in addition to older biochemical studies that empirically used heme to inhibit proteasome function in biochemical assays, led us to the hypothesis that excessive intracellular heme could disrupt cellular protein homeostasis by an inhibitory action on the proteasome. PubMed:25301065

Appears in Networks:
Annotations
Text Location
Results

bp(GO:"cellular homeostasis") negativeCorrelation a(CHEBI:heme) View Subject | View Object

The proteasome is the principal pathway to remove senescent and damaged proteins, and intact proteasome function is essential to preserve and repair cellular homeostasis during oxidative stress, such as that triggered by heme exposure.27 PubMed:25301065

Appears in Networks:
Annotations
Text Location
Discussion

bp(GO:"cellular homeostasis") positiveCorrelation act(p(PFAM:Proteasome)) View Subject | View Object

The proteasome is the principal pathway to remove senescent and damaged proteins, and intact proteasome function is essential to preserve and repair cellular homeostasis during oxidative stress, such as that triggered by heme exposure.27 PubMed:25301065

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Text Location
Discussion

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.