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  3. p(HGNC:MAPT, var("p.D421*"))

p(HGNC:MAPT, var("p.D421*"))

Equivalencies: 0 | Classes: 1 | Children: 0 | Explore

Entity

Name
MAPT
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 1

Tau clearance mechanisms and their possible role in the pathogenesis of Alzheimer disease v1.0.0

In-Edges 2

p(HGNC:MAPT) hasVariant p(HGNC:MAPT, var("p.D421*")) View Subject | View Object

Appears in Networks:

act(p(HGNC:CASP6)) increases p(HGNC:MAPT, var("p.D421*")) View Subject | View Object

Caspase-6 was also shown to cleave the N-terminus of tau in vitro (24). Caspase-3, which is a key effector in the apoptotic cascade, cleaves tau predominantly at the C-terminal D421 site generating a fragment often referred to as tauC3 (22, 23). PubMed:24027553

Appears in Networks:
Annotations
Text Location
Review

Out-Edges 1

p(HGNC:MAPT, var("p.D421*")) isA p(HBP:"Tau C3") View Subject | View Object

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.