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  3. complex(p(HGNC:IGBP1), p(HGNC:PPP2CA))

complex(p(HGNC:IGBP1), p(HGNC:PPP2CA))

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Components

Appears in Networks 2

Assembly and structure of protein phosphatase 2A v1.0.0

Protein phosphatase 2A dysfunction in Alzheimer’s disease v1.0.0

In-Edges 1

p(HGNC:PPP2CA, pmod(Me)) decreases complex(p(HGNC:IGBP1), p(HGNC:PPP2CA)) View Subject | View Object

Intriguingly, changes in this peptide motif also affected interaction of the catalytic subunit with the alpha4 protein (α4), presumably through alteration of methylation[ 29], and led to a complex with distinct substrate specificity that is essential for cell survival PubMed:19277525

Appears in Networks:

Out-Edges 3

complex(p(HGNC:IGBP1), p(HGNC:PPP2CA)) hasComponent p(HGNC:IGBP1) View Subject | View Object

Appears in Networks:

complex(p(HGNC:IGBP1), p(HGNC:PPP2CA)) hasComponent p(HGNC:PPP2CA) View Subject | View Object

Appears in Networks:

complex(p(HGNC:IGBP1), p(HGNC:PPP2CA)) regulates complex(GO:"protein phosphatase type 2A complex") View Subject | View Object

Furthermore, direct interaction of PP2A catalytic subunit with specific regulatory proteins, including PME-1, LCMT1, the alpha4 subunit, and the PP2A phosphatase activator PTPA, critically modulates PP2A biogenesis and stability PubMed:24653673

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.