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r(HGNC:NOS2)

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Entity

Name
NOS2
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 2

Tau Modifications v1.9.5

Tau Modifications Sections of NESTOR

Chronic Anatabine Treatment Reduces Alzheimer ’ s Disease (AD)-Like Pathology and Improves Socio-Behavioral Deficits in a Transgenic Mouse Model of AD v1.0.0

In-Edges 5

a(CHEBI:"quinolinic acid") increases r(HGNC:NOS2) View Subject | View Object

Using PCR arrays, QA significantly induces 10 genes in human neurons known to be associated with AD pathology with 6 belonging to pathways involved in tau phosphorylation and 4 of them in neuroprotection. PubMed:19623258

Appears in Networks:

complex(p(FPLX:CEBP), p(HGNC:SUMO1)) directlyDecreases r(HGNC:NOS2) View Subject | View Object

Noradrenaline (NA) attenuated the LPS-induced reductions and increased SUMO-1 above basal levels. Over-expression of SUMO-1, Ubc9, or SENP1 reduced the activation of a NOS2 promoter, whereas activation of a 4 x NFkappaB binding-element reporter was only reduced by SUMO-1. ChIP studies revealed interactions of SUMO-1 and C/EBPbeta with C/EBP binding sites on the NOS2 promoter that were modulated by LPS and NA. SUMO-1 co-precipitated with C/EBPbeta confirmed by FRET analysis PubMed:19323834

Appears in Networks:

p(HGNC:SENP1) directlyDecreases r(HGNC:NOS2) View Subject | View Object

Noradrenaline (NA) attenuated the LPS-induced reductions and increased SUMO-1 above basal levels. Over-expression of SUMO-1, Ubc9, or SENP1 reduced the activation of a NOS2 promoter, whereas activation of a 4 x NFkappaB binding-element reporter was only reduced by SUMO-1. ChIP studies revealed interactions of SUMO-1 and C/EBPbeta with C/EBP binding sites on the NOS2 promoter that were modulated by LPS and NA. SUMO-1 co-precipitated with C/EBPbeta confirmed by FRET analysis PubMed:19323834

Appears in Networks:

p(HGNC:UBE2I) directlyDecreases r(HGNC:NOS2) View Subject | View Object

Noradrenaline (NA) attenuated the LPS-induced reductions and increased SUMO-1 above basal levels. Over-expression of SUMO-1, Ubc9, or SENP1 reduced the activation of a NOS2 promoter, whereas activation of a 4 x NFkappaB binding-element reporter was only reduced by SUMO-1. ChIP studies revealed interactions of SUMO-1 and C/EBPbeta with C/EBP binding sites on the NOS2 promoter that were modulated by LPS and NA. SUMO-1 co-precipitated with C/EBPbeta confirmed by FRET analysis PubMed:19323834

Appears in Networks:

a(CHEBI:Anatabine) decreases r(HGNC:NOS2) View Subject | View Object

A dose dependent suppression of iNOS transcription was observed in Tg PS1/APPswe mice treated with anata- bine at a dosage of 10 or 20 mg/Kg/Day compared to untreated Tg PS1/APPswe mice (Fig 10). PubMed:26010758

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

Out-Edges 0

About

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.