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complex(a(CHEBI:heme), a(HM:"Atheroma lipid"))

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Components

Appears in Networks 1

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 0

Out-Edges 6

complex(a(CHEBI:heme), a(HM:"Atheroma lipid")) hasComponent a(CHEBI:heme) View Subject | View Object

Appears in Networks:

complex(a(CHEBI:heme), a(HM:"Atheroma lipid")) hasComponent a(HM:"Atheroma lipid") View Subject | View Object

Appears in Networks:

complex(a(CHEBI:heme), a(HM:"Atheroma lipid")) increases a(MESH:"Thiobarbituric Acid Reactive Substances") View Subject | View Object

As is true of intact hemoglobin, lipid extracts from atheromatous lesions exposed to heme also underwent lipid peroxidation as reflected by the accumulation of thiobarbituric acid-reactive substances (TBARs) and lipid hydroperoxides (supplemental Fig I). PubMed:20378845

Appears in Networks:
Annotations
Cell Ontology (CL)
endothelial cell
MeSH
Plaque, Atherosclerotic
Text Location
Results

complex(a(CHEBI:heme), a(HM:"Atheroma lipid")) increases a(CHEBI:"lipid hydroperoxide") View Subject | View Object

As is true of intact hemoglobin, lipid extracts from atheromatous lesions exposed to heme also underwent lipid peroxidation as reflected by the accumulation of thiobarbituric acid-reactive substances (TBARs) and lipid hydroperoxides (supplemental Fig I). PubMed:20378845

Appears in Networks:
Annotations
Cell Ontology (CL)
endothelial cell
MeSH
Plaque, Atherosclerotic
Text Location
Results

complex(a(CHEBI:heme), a(HM:"Atheroma lipid")) increases bp(MESH:"Lipid Peroxidation") View Subject | View Object

As is true of intact hemoglobin, lipid extracts from atheromatous lesions exposed to heme also underwent lipid peroxidation as reflected by the accumulation of thiobarbituric acid-reactive substances (TBARs) and lipid hydroperoxides (supplemental Fig I). PubMed:20378845

Appears in Networks:
Annotations
Cell Ontology (CL)
endothelial cell
MeSH
Plaque, Atherosclerotic
Text Location
Results

complex(a(CHEBI:heme), a(HM:"Atheroma lipid")) increases p(HGNC:HMOX1) View Subject | View Object

Now we demonstrate that heme and hemoglobin-treated atheroma lipids also induce HO-1 in endothelial cells exposed in sublethal doses. PubMed:20378845

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Atherosclerosis
Text Location
Discussion

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.