a(CHEBI:cinnamaldehyde)

Entity

Name

cinnamaldehyde

Namespace

chebi

Namespace Version

20180906

Namespace URL

https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/chebi-names.belns

Tau Modifications Sections of NESTOR

CA and the oxidized form of EC (ECox) inhibited tau aggregation in vitro due to their interaction with the two cysteine residues in tau. A synthetic peptide, SKCGS, representing the actual tau sequence, identified the thiol as reacting with CA and ECox which necessitates of cysteine for aggregation inhibition by CA. PubMed:23531502

CA and the oxidized form of EC (ECox) inhibited tau aggregation in vitro due to their interaction with the two cysteine residues in tau. A synthetic peptide, SKCGS, representing the actual tau sequence, identified the thiol as reacting with CA and ECox which necessitates of cysteine for aggregation inhibition by CA. PubMed:23531502

The data (Fig. 8B) shows that no significant difference in the extent of tubulin assembly could be observed with normal tau or tau incubated with CA. These results also indicate that once assembled, the microtubules remained stable to the same extent in the presence or in the absence of CA. PubMed:23531502

We found that CA (lane 4) and EC (lane 6) substantially prevented the H2O2 induced formation of the high molecular weight species. PubMed:23531502