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a(PUBCHEM:73078)

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Entity

Name
73078
Namespace
PUBCHEM
Namespace Version
None
Pattern
^\d+$

Appears in Networks 1

Phytochemicals as inhibitors of NF-κB for treatment of Alzheimer’s disease v1.0.0

In-Edges 0

Out-Edges 11

a(PUBCHEM:73078) decreases act(p(FPLX:NFkappaB)) View Subject | View Object

Tetrandrine inhibited the activity of NF-B and down-regulated the expression of pro-inflammatory cytokines [178–180]. PubMed:29179999

Appears in Networks:

a(PUBCHEM:73078) decreases act(p(FPLX:NFkappaB)) View Subject | View Object

It ameliorated spatial learning and memory disorder, which was caused by A 1-42 and was associated with the inter-ference of NF-B activity and the inhibition of IL-1 and TNF-expression [183]. PubMed:29179999

Appears in Networks:

a(PUBCHEM:73078) decreases a(MESH:Cytokines) View Subject | View Object

Tetrandrine inhibited the activity of NF-B and down-regulated the expression of pro-inflammatory cytokines [178–180]. PubMed:29179999

Appears in Networks:

a(PUBCHEM:73078) decreases deg(p(HGNC:NFKBIA)) View Subject | View Object

It inhibited the degradation of IkBa, a cytoplasmic NF-B inhibitor, and p65translocation to the nucleus by disabling IkBa alpha kinase beta and  activiies [181,182]. PubMed:29179999

Appears in Networks:

a(PUBCHEM:73078) decreases tloc(p(HGNC:RELA), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus")) View Subject | View Object

It inhibited the degradation of IkBa, a cytoplasmic NF-B inhibitor, and p65translocation to the nucleus by disabling IkBa alpha kinase beta and  activiies [181,182]. PubMed:29179999

Appears in Networks:

a(PUBCHEM:73078) decreases act(p(HGNC:CHUK)) View Subject | View Object

It inhibited the degradation of IkBa, a cytoplasmic NF-B inhibitor, and p65translocation to the nucleus by disabling IkBa alpha kinase beta and  activiies [181,182]. PubMed:29179999

Appears in Networks:

a(PUBCHEM:73078) decreases act(p(HGNC:IKBKB)) View Subject | View Object

It inhibited the degradation of IkBa, a cytoplasmic NF-B inhibitor, and p65translocation to the nucleus by disabling IkBa alpha kinase beta and  activiies [181,182]. PubMed:29179999

Appears in Networks:

a(PUBCHEM:73078) increases path(MESH:"Spatial Learning") View Subject | View Object

It ameliorated spatial learning and memory disorder, which was caused by A 1-42 and was associated with the inter-ference of NF-B activity and the inhibition of IL-1 and TNF-expression [183]. PubMed:29179999

Appears in Networks:

a(PUBCHEM:73078) increases bp(GO:memory) View Subject | View Object

It ameliorated spatial learning and memory disorder, which was caused by A 1-42 and was associated with the inter-ference of NF-B activity and the inhibition of IL-1 and TNF-expression [183]. PubMed:29179999

Appears in Networks:

a(PUBCHEM:73078) decreases p(HGNC:IL1B) View Subject | View Object

It ameliorated spatial learning and memory disorder, which was caused by A 1-42 and was associated with the inter-ference of NF-B activity and the inhibition of IL-1 and TNF-expression [183]. PubMed:29179999

Appears in Networks:

a(PUBCHEM:73078) decreases p(HGNC:TNF) View Subject | View Object

It ameliorated spatial learning and memory disorder, which was caused by A 1-42 and was associated with the inter-ference of NF-B activity and the inhibition of IL-1 and TNF-expression [183]. PubMed:29179999

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.