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bp(HBP:HBP00068)

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Entity

Name
HBP00068
Namespace
HBP
Namespace Version
20181029
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/785431732a26d6809b4162d98b95687d16404e63/export/hbp.belns

Appears in Networks 2

Amyloid β oligomers (AβOs) in Alzheimer’s disease v1.0.0

APP processing in Alzheimer's disease v1.0.1

APP processing in Alzheimer's disease

In-Edges 3

act(p(HGNC:GRIN1)) increases bp(HBP:HBP00068) View Subject | View Object

Excessive activation of NMDAR by soluble AβOs triggers disproportionate influx of Ca2+ into neurons, which leads to excitotoxicity, mitochondrial dysfunction, and loss of synapses (Zhao et al. 2004). PubMed:29196815

Appears in Networks:
Annotations
MeSH
Extracellular Space
Cell Ontology (CL)
neuron
Confidence
Medium

a(HBP:HBP00067) decreases bp(HBP:HBP00068) View Subject | View Object

In contrast to Abeta, sAPPalpha has an important role in neuronal plasticity/survival and is protective against excitotoxicity [42,43]. sAPPalpha also regulates neural stem cell proliferation and is important for early CNS development [57,58] PubMed:21214928

Appears in Networks:
Annotations
Confidence
High
MeSH
Temporal Lobe

a(HBP:HBP00067) decreases bp(HBP:HBP00068) View Subject | View Object

We and others have also found that sAPPalpha can inhibit stress-induced CDK5 activation and participate in various neuroprotective reagent-mediated excitoprotection [44,59-61] PubMed:21214928

Appears in Networks:
Annotations
Confidence
High
MeSH
Neurons

Out-Edges 0

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.