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  3. a(HBP:HBP00078)

a(HBP:HBP00078)

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
HBP00078
Namespace
HBP
Namespace Version
20181029
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/785431732a26d6809b4162d98b95687d16404e63/export/hbp.belns

Appears in Networks 1

Proteolytic processing of Alzeimer's beta-amyloid precursor protein v1.0.1

In-Edges 2

p(HGNC:APP) association a(HBP:HBP00078) View Subject | View Object

The extracellular portion of APP contains E1 and E2 domains and a Kunitz protease inhibitor (KPI) domain that is missing in APP695 (Kang and Muller-Hill 1990; Rohan de Silva et al. 1997) PubMed:22122372

Appears in Networks:
Annotations
Confidence
High
MeSH
Neurons

complex(a(HBP:HBP00078), a(HBP:HBP00079)) hasComponent a(HBP:HBP00078) View Subject | View Object

Appears in Networks:

Out-Edges 4

a(HBP:HBP00078) association p(HGNC:APP) View Subject | View Object

The extracellular portion of APP contains E1 and E2 domains and a Kunitz protease inhibitor (KPI) domain that is missing in APP695 (Kang and Muller-Hill 1990; Rohan de Silva et al. 1997) PubMed:22122372

Appears in Networks:
Annotations
Confidence
High
MeSH
Neurons

a(HBP:HBP00078) increases complex(p(HGNC:APP), p(HGNC:APP)) View Subject | View Object

The E1 domain is reported to function as the major interaction interface for dimerization of cellular APP/APLPs (Soba et al. 2005) PubMed:22122372

Appears in Networks:
Annotations
Confidence
High
MeSH
Neurons

a(HBP:HBP00078) increases complex(p(HGNC:APLP1), p(HGNC:APLP1)) View Subject | View Object

The E1 domain is reported to function as the major interaction interface for dimerization of cellular APP/APLPs (Soba et al. 2005) PubMed:22122372

Appears in Networks:
Annotations
Confidence
High
MeSH
Neurons

a(HBP:HBP00078) increases complex(p(HGNC:APLP2), p(HGNC:APLP2)) View Subject | View Object

The E1 domain is reported to function as the major interaction interface for dimerization of cellular APP/APLPs (Soba et al. 2005) PubMed:22122372

Appears in Networks:
Annotations
Confidence
High
MeSH
Neurons

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.