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Appears in Networks 1

In-Edges 1

path(MESH:"Amyotrophic Lateral Sclerosis") increases p(HGNC:RNF19A) View Subject | View Object

Interestingly, dorfin expression is increased in the spinal cord of ALS patients (Ishigaki et al., 2002), which may suggest that the expression of the E3 ligase is increased in an attempt to enhance clearance of the mutant SOD1. PubMed:14556719

Out-Edges 3

p(HGNC:RNF19A) decreases bp(GO:"cell death") View Subject | View Object

Similarly, overexpression of the putative SOD1 E3 ligase dorfin can inhibit cell death induced by the mutant protein (Niwa et al., 2002), presumably by promoting its removal via the UPS. PubMed:14556719

p(HGNC:RNF19A) increases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") View Subject | View Object

Similarly, overexpression of the putative SOD1 E3 ligase dorfin can inhibit cell death induced by the mutant protein (Niwa et al., 2002), presumably by promoting its removal via the UPS. PubMed:14556719

p(HGNC:RNF19A) increases deg(p(HGNC:SOD1, var("?"))) View Subject | View Object

Interestingly, dorfin expression is increased in the spinal cord of ALS patients (Ishigaki et al., 2002), which may suggest that the expression of the E3 ligase is increased in an attempt to enhance clearance of the mutant SOD1. PubMed:14556719

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.