1. Catalog
  2. Nodes
  3. p(HGNC:MAPT, var("p.Arg5His"))

p(HGNC:MAPT, var("p.Arg5His"))

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
MAPT
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 1

Tau in physiology and pathology v1.0.0

In-Edges 1

p(HGNC:MAPT) hasVariant p(HGNC:MAPT, var("p.Arg5His")) View Subject | View Object

Appears in Networks:

Out-Edges 3

p(HGNC:MAPT, var("p.Arg5His")) decreases complex(p(HGNC:DCTN1), p(HGNC:MAPT)) View Subject | View Object

Another mutation (R5H or R5L) outside the microtubule-binding domain disrupts the binding of tau to the p150 subunit of the dynactin complex — an essential cofactor for the microtubule motor dynein —thereby possibly interfering with general axonal transport PubMed:26631930

Appears in Networks:

p(HGNC:MAPT, var("p.Arg5His")) decreases bp(GO:"axonal transport") View Subject | View Object

Another mutation (R5H or R5L) outside the microtubule-binding domain disrupts the binding of tau to the p150 subunit of the dynactin complex — an essential cofactor for the microtubule motor dynein —thereby possibly interfering with general axonal transport PubMed:26631930

Appears in Networks:

p(HGNC:MAPT, var("p.Arg5His")) decreases act(p(HGNC:MAPT)) View Subject | View Object

Some tau mutations (such as A152T and R5H) may cause loss of tau function as well (as discussed above) PubMed:26631930

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.