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Appears in Networks 2

In-Edges 4

a(PUBCHEM:6324599) decreases act(p(HGNC:P2RX7)) View Subject | View Object

In addition, Brilliant Blue G (BBG), a P2X7 receptor antagonist, inhibits ATP-induced activation of the NLRP2 inflammasome in human astrocytes (Minkiewicz et al., 2013) PubMed:24561250

Annotations
Cell Ontology (CL)
astrocyte
Confidence
Medium

a(MESH:Microglia) increases p(HGNC:P2RX7) View Subject | View Object

P2X7 expressed by microglial cells will also activate the NLP3 inflammasome [30, 32] and the expression of P2X7 is likely to be increased in AD brains [35]. PubMed:27314526

path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:P2RX7) View Subject | View Object

P2X7 expressed by microglial cells will also activate the NLP3 inflammasome [30, 32] and the expression of P2X7 is likely to be increased in AD brains [35]. PubMed:27314526

Out-Edges 7

p(HGNC:P2RX7) increases act(complex(GO:"NLRP1 inflammasome complex")) View Subject | View Object

A subsequent study demonstrated that P2X7 purinergic receptor is involved in the activation of NLRP1 inflammasome (Silverman et al., 2009) PubMed:24561250

Annotations
Confidence
High

p(HGNC:P2RX7) increases act(complex(GO:"NLRP1 inflammasome complex")) View Subject | View Object

Similarly, the P2X7 purinergic receptor has been shown to activate the NLRP1 inflammasome in primary neurons (Silverman et al., 2009) PubMed:24561250

Annotations
Confidence
High

act(p(HGNC:P2RX7)) increases bp(GO:"inflammatory response") View Subject | View Object

P2X7 activation is followed by a number of downstream events, including release of pro-inflammatory mediators, cell death, and proliferation. PubMed:27314526

act(p(HGNC:P2RX7)) increases bp(GO:"apoptotic process") View Subject | View Object

P2X7 activation is followed by a number of downstream events, including release of pro-inflammatory mediators, cell death, and proliferation. PubMed:27314526

act(p(HGNC:P2RX7)) increases bp(GO:"cell proliferation") View Subject | View Object

P2X7 activation is followed by a number of downstream events, including release of pro-inflammatory mediators, cell death, and proliferation. PubMed:27314526

p(HGNC:P2RX7) increases act(complex(GO:"NLRP3 inflammasome complex")) View Subject | View Object

P2X7 expressed by microglial cells will also activate the NLP3 inflammasome [30, 32] and the expression of P2X7 is likely to be increased in AD brains [35]. PubMed:27314526

p(HGNC:P2RX7) positiveCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

P2X7 expressed by microglial cells will also activate the NLP3 inflammasome [30, 32] and the expression of P2X7 is likely to be increased in AD brains [35]. PubMed:27314526

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.