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a(CHEBI:epibatidine)

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Entity

Name
epibatidine
Namespace
chebi
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/chebi-names.belns

Appears in Networks 6

albuquerque2009 v1.0.0

This file encodes the article Mammalian Nicotinic Acetylcholine Receptors: From Structure to Function by Albuquerque et al, 2009

Nicotinic acetylcholine receptor signalling: roles in Alzheimer's disease and amyloid neuroprotection. v1.0.0

NACHO Mediates Nicotinic Acetylcholine Receptor Function throughout the Brain v1.0.0

Nicotinic Receptor Abnormalities of Alzheimer’s Disease: Therapeutic Implications v1.0.0

B-973, a novel piperazine positive allosteric modulator of the α7 nicotinic acetylcholine receptor v1.0.0

Up-regulation of Nicotinic Receptors by Nicotine Varies with Receptor Subtype v1.0.0

In-Edges 13

a(TAXONOMY:92736) increases a(CHEBI:epibatidine) View Subject | View Object

More recently, epibatidine, an alkaloid from the skin of the Ecuadorain tree frog Epipedobates tricolor, revealed another example of how a nicotinic agonist can produce toxic effects (111, 130). In addition to being a potent analgesic, when injected into mice at a relatively low dose (0.4 microg/mouse), this compound produced straub tail reaction. The major target of epibatidine is the alpha4beta2 high-affinity nAChR, although other nAChRs are targeted with various affinities (e.g., Ref. 507). PubMed:19126755

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Annotations
Text Location
Review

complex(a(CHEBI:epibatidine), p(HBP:"alpha-4 beta-2 nAChR")) hasComponent a(CHEBI:epibatidine) View Subject | View Object

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complex(a(CHEBI:epibatidine), p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) hasComponent a(CHEBI:epibatidine) View Subject | View Object

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complex(a(CHEBI:epibatidine), a(MESH:"nicotinic receptor alpha3beta4")) hasComponent a(CHEBI:epibatidine) View Subject | View Object

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complex(a(CHEBI:epibatidine), p(FPLX:CHRN)) hasComponent a(CHEBI:epibatidine) View Subject | View Object

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complex(a(CHEBI:epibatidine), a(HBP:HBP00174)) hasComponent a(CHEBI:epibatidine) View Subject | View Object

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complex(a(CHEBI:epibatidine), a(HBP:HBP00180)) hasComponent a(CHEBI:epibatidine) View Subject | View Object

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complex(a(CHEBI:epibatidine), a(MESH:"alpha6beta2 nicotinic acetylcholine receptor")) hasComponent a(CHEBI:epibatidine) View Subject | View Object

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complex(a(CHEBI:epibatidine), a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) hasComponent a(CHEBI:epibatidine) View Subject | View Object

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complex(a(CHEBI:epibatidine), a(MESH:"nicotinic receptor alpha3beta2")) hasComponent a(CHEBI:epibatidine) View Subject | View Object

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complex(a(CHEBI:epibatidine), p(HGNC:CHRNA4)) hasComponent a(CHEBI:epibatidine) View Subject | View Object

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complex(a(CHEBI:epibatidine), a(HBP:"alpha-3 beta-2 nAChR")) hasComponent a(CHEBI:epibatidine) View Subject | View Object

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complex(a(CHEBI:epibatidine), a(HBP:"alpha-4 beta-2 nAChR")) hasComponent a(CHEBI:epibatidine) View Subject | View Object

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Out-Edges 5

a(CHEBI:epibatidine) causesNoChange bp(GO:memory) View Subject | View Object

The loss of nAChR subunits, as determined by [3H]- epibatidine binding, seems to take place after the transition from mild cognitive impairment (MCI) to AD (Sabbagh et al., 2006), although the loss of epibatidine binding did not correlate with decline in memory, cognitive performance, or with the development of neurofibrillary tangles or plaques (Sabbagh et al., 2001). PubMed:19293145

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a(CHEBI:epibatidine) causesNoChange bp(GO:cognition) View Subject | View Object

The loss of nAChR subunits, as determined by [3H]- epibatidine binding, seems to take place after the transition from mild cognitive impairment (MCI) to AD (Sabbagh et al., 2006), although the loss of epibatidine binding did not correlate with decline in memory, cognitive performance, or with the development of neurofibrillary tangles or plaques (Sabbagh et al., 2001). PubMed:19293145

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a(CHEBI:epibatidine) causesNoChange path(MESH:"Plaque, Amyloid") View Subject | View Object

The loss of nAChR subunits, as determined by [3H]- epibatidine binding, seems to take place after the transition from mild cognitive impairment (MCI) to AD (Sabbagh et al., 2006), although the loss of epibatidine binding did not correlate with decline in memory, cognitive performance, or with the development of neurofibrillary tangles or plaques (Sabbagh et al., 2001). PubMed:19293145

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a(CHEBI:epibatidine) causesNoChange bp(MESH:"Neurofibrillary Tangles") View Subject | View Object

The loss of nAChR subunits, as determined by [3H]- epibatidine binding, seems to take place after the transition from mild cognitive impairment (MCI) to AD (Sabbagh et al., 2006), although the loss of epibatidine binding did not correlate with decline in memory, cognitive performance, or with the development of neurofibrillary tangles or plaques (Sabbagh et al., 2001). PubMed:19293145

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a(CHEBI:epibatidine) decreases complex(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor"), a(PUBCHEM:16068384)) View Subject | View Object

As expected, binding was inhibited by epibatidine (Fig. 5A) PubMed:28132910

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BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.