bp(GO:"protein polyubiquitination")

Entity

Name

protein polyubiquitination

Namespace

go

Namespace Version

20180921

Namespace URL

https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/go-names.belns

In some other cases, the first ubiquitin moiety is conjugated to the substrate by one E3, while chain elongation is catalyzed by a different ligase, often termed E4 PubMed:14556719

One key take-home message is that many E3 ligases likely evolved to be processive, meaning that they can conjugate multiple ubiquitins onto a substrate before it is released from enzyme PubMed:24457024

In this model,accumulation of an Hsp70–substrate complex (either via treatment with chemical inhibitors or because of intrinsic properties of the substrate) might allow enough time for a degradation factor (e.g., CHIP) to bind and facilitate polyubiquitination. PubMed:21882945

An E4 enzyme catalyzes the polyubiquitination of the target substrate that is bound to the E2–E3 complexes PubMed:22908190