1. Catalog
  2. Nodes
  3. p(HBP:"AT8 tau")

p(HBP:"AT8 tau")

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
AT8 tau
Namespace
HBP
Namespace Version
None
Pattern
.*

Appears in Networks 1

Pathogenic forms of tau inhibit kinesin-dependent axonal transport through a mechanism involving activation of axonal phosphotransferases. v1.0.0

In-Edges 0

Out-Edges 4

p(HBP:"AT8 tau") hasVariant p(HBP:"AT8 tau", pmod(Ph)) View Subject | View Object

Appears in Networks:

p(HBP:"AT8 tau") decreases bp(GO:"anterograde axonal protein transport") View Subject | View Object

Soluble AT8 tau monomers inhibited anterograde FAT (Fig. 6 A, C), while retrograde trans- port was unaffected (Fig. 6 A, D). These data indicate that phos- phorylation of tau at the AT8 epitope, which is associated with hyperphosphorylation of tau in AD and other tauopathies, renders soluble monomeric tau capable of inhibiting antero- grade FAT. PubMed:21734277

Appears in Networks:

p(HBP:"AT8 tau") causesNoChange bp(GO:"retrograde axonal protein transport") View Subject | View Object

Soluble AT8 tau monomers inhibited anterograde FAT (Fig. 6 A, C), while retrograde trans- port was unaffected (Fig. 6 A, D). These data indicate that phos- phorylation of tau at the AT8 epitope, which is associated with hyperphosphorylation of tau in AD and other tauopathies, renders soluble monomeric tau capable of inhibiting antero- grade FAT. PubMed:21734277

Appears in Networks:

p(HBP:"AT8 tau") causesNoChange act(p(HBP:"6D tau", frag("2_18"))) View Subject | View Object

Together, these data suggest that increased PAD exposure represents an early event in AD pathogenesis and that AT8 may not be required for PAD ex- posure in situ. PubMed:21734277

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.