a(PUBCHEM:877863)
A screen for autophagy inducers in yeast identified the molecules SMER-10, -18, and -28 as TOR-independent activators of autophagy (146). PubMed:25784053
Treatment of PC12 cells stably expressing mutant α-synuclein (A53T) with SMER-10, -18, or-28 significantly reduced levels of mutant α-synuclein, an effect that was enhanced by cotreatment with rapamycin (146). PubMed:25784053
In addition, SMER-10, -18, and -28 were effective at suppressing mHTT aggregation and toxicity in COS-7 cells and flies (146). PubMed:25784053
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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.