a(MESH:"Heat-Shock Proteins")
Several members of the chaperone family are upregulated in response to stress and, thus, these factors have been termed heat shock proteins (Hsps) PubMed:21882945
The expression of Hsps is regulated by heat shock factor 1 (HSF1), which, under stress conditions, becomes associated with heat shock elements to elevate the transcription of Hsps and other proteins [51]. PubMed:21882945
Many are stress proteins or heat shock proteins (Hsps), as their synthesis is induced under conditions of stress (e.g., heat shock or oxidative stress), which structurally destabilize a subset of cellular proteins. PubMed:23746257
Many are stress proteins or heat shock proteins (Hsps), as their synthesis is induced under conditions of stress (e.g., heat shock or oxidative stress), which structurally destabilize a subset of cellular proteins. PubMed:23746257
Many are stress proteins or heat shock proteins (Hsps), as their synthesis is induced under conditions of stress (e.g., heat shock or oxidative stress), which structurally destabilize a subset of cellular proteins. PubMed:23746257
HSF1 binds to a consensus heat shock element (HSE) within the promoter regions of HSP genes resulting in the activation of HSPs' gene expression and the control of cellular responses to oxidative and proteotoxic stress [108]. PubMed:24563850
Importantly, the Hsps are also critical at the end of a protein’s life, as they facilitate turnover by the proteasome system and the clearance of proteotoxic aggregates by autophagy [53] PubMed:21882945
Importantly, the Hsps are also critical at the end of a protein’s life, as they facilitate turnover by the proteasome system and the clearance of proteotoxic aggregates by autophagy [53] PubMed:21882945
HSF1 binds to a consensus heat shock element (HSE) within the promoter regions of HSP genes resulting in the activation of HSPs' gene expression and the control of cellular responses to oxidative and proteotoxic stress [108]. PubMed:24563850
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