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composite(a(CHEBI:nicotine), complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2)))

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Nicotinic acetylcholine receptor signalling: roles in Alzheimer's disease and amyloid neuroprotection. v1.0.0

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Out-Edges 4

composite(a(CHEBI:nicotine), complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2))) hasComponent a(CHEBI:nicotine) View Subject | View Object

Appears in Networks:

composite(a(CHEBI:nicotine), complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2))) hasComponent complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2)) View Subject | View Object

Appears in Networks:

composite(a(CHEBI:nicotine), complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2))) decreases sec(a(CHEBI:"amyloid-beta")) View Subject | View Object

In addition to Abeta acting upon nAChRs, nAChRs in turn regulate Abeta secretion. Nicotine or epibatidine applied to the human SHEP1 cell line stably transfected with human alpha4beta2 nAChRs and human APP decreases the secretion and intracellular accumulation of Abeta without significantly affecting the APP mRNA, suggesting that these effects are post-translational (Nie et al., 2007). PubMed:19293145

Appears in Networks:

composite(a(CHEBI:nicotine), complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2))) causesNoChange r(HGNC:APP) View Subject | View Object

In addition to Abeta acting upon nAChRs, nAChRs in turn regulate Abeta secretion. Nicotine or epibatidine applied to the human SHEP1 cell line stably transfected with human alpha4beta2 nAChRs and human APP decreases the secretion and intracellular accumulation of Abeta without significantly affecting the APP mRNA, suggesting that these effects are post-translational (Nie et al., 2007). PubMed:19293145

Appears in Networks:

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BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.