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p(HBP:"APP, ACR")

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Entity

Name
APP, ACR
Namespace
HBP
Namespace Version
20181119
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/90e1cb9e5e882703380c9db8d4915ac6f3cba137/export/hbp-names.belns

Appears in Networks 1

Tau Modifications v1.9.5

Tau Modifications Sections of NESTOR

In-Edges 2

p(HBP:"CRL4 complex") association p(HBP:"APP, ACR") View Subject | View Object

the ACR (APP cytosolic region) interacts with the E3 ubiquitin-protein ligases Stub1, which binds the NH2 terminus of the ACR, and CRL4(CRBN), which is formed by Cul4a/b, Ddb1, and Crbn, and interacts with the COOH terminus of the ACR via Crbn. PubMed:27325702

Appears in Networks:

p(HGNC:STUB1) association p(HBP:"APP, ACR") View Subject | View Object

the ACR (APP cytosolic region) interacts with the E3 ubiquitin-protein ligases Stub1, which binds the NH2 terminus of the ACR, and CRL4(CRBN), which is formed by Cul4a/b, Ddb1, and Crbn, and interacts with the COOH terminus of the ACR via Crbn. PubMed:27325702

Appears in Networks:

Out-Edges 18

p(HBP:"APP, ACR") association p(HGNC:STUB1) View Subject | View Object

the ACR (APP cytosolic region) interacts with the E3 ubiquitin-protein ligases Stub1, which binds the NH2 terminus of the ACR, and CRL4(CRBN), which is formed by Cul4a/b, Ddb1, and Crbn, and interacts with the COOH terminus of the ACR via Crbn. PubMed:27325702

Appears in Networks:

p(HBP:"APP, ACR") association p(HBP:"CRL4 complex") View Subject | View Object

the ACR (APP cytosolic region) interacts with the E3 ubiquitin-protein ligases Stub1, which binds the NH2 terminus of the ACR, and CRL4(CRBN), which is formed by Cul4a/b, Ddb1, and Crbn, and interacts with the COOH terminus of the ACR via Crbn. PubMed:27325702

Appears in Networks:

p(HBP:"APP, ACR") increases p(HGNC:SCAMP1, pmod(Ub)) View Subject | View Object

As reported in Table 6, several brain-derived proteins associated with the ACR bait were ubiquitinated. These proteins can be separated into four groups as follows: (a) group 1, proteins of the ubiquitin-conjugating system; (b) group 2, presynaptic proteins; (c) group 3, other proteins implicated in AD; and (d) group 4, phosphorylation-dependent ACR interactors. PubMed:27325702

Appears in Networks:

p(HBP:"APP, ACR") increases p(HGNC:SV2A, pmod(Ub)) View Subject | View Object

As reported in Table 6, several brain-derived proteins associated with the ACR bait were ubiquitinated. These proteins can be separated into four groups as follows: (a) group 1, proteins of the ubiquitin-conjugating system; (b) group 2, presynaptic proteins; (c) group 3, other proteins implicated in AD; and (d) group 4, phosphorylation-dependent ACR interactors. PubMed:27325702

Appears in Networks:

p(HBP:"APP, ACR") increases p(HGNC:SV2B, pmod(Ub)) View Subject | View Object

As reported in Table 6, several brain-derived proteins associated with the ACR bait were ubiquitinated. These proteins can be separated into four groups as follows: (a) group 1, proteins of the ubiquitin-conjugating system; (b) group 2, presynaptic proteins; (c) group 3, other proteins implicated in AD; and (d) group 4, phosphorylation-dependent ACR interactors. PubMed:27325702

Appears in Networks:

p(HBP:"APP, ACR") increases p(HGNC:VAMP2, pmod(Ub)) View Subject | View Object

As reported in Table 6, several brain-derived proteins associated with the ACR bait were ubiquitinated. These proteins can be separated into four groups as follows: (a) group 1, proteins of the ubiquitin-conjugating system; (b) group 2, presynaptic proteins; (c) group 3, other proteins implicated in AD; and (d) group 4, phosphorylation-dependent ACR interactors. PubMed:27325702

Appears in Networks:

p(HBP:"APP, ACR") increases p(HGNC:ATP6V0A1, pmod(Ub)) View Subject | View Object

As reported in Table 6, several brain-derived proteins associated with the ACR bait were ubiquitinated. These proteins can be separated into four groups as follows: (a) group 1, proteins of the ubiquitin-conjugating system; (b) group 2, presynaptic proteins; (c) group 3, other proteins implicated in AD; and (d) group 4, phosphorylation-dependent ACR interactors. PubMed:27325702

Appears in Networks:

p(HBP:"APP, ACR") increases p(HGNC:SLC17A7, pmod(Ub)) View Subject | View Object

As reported in Table 6, several brain-derived proteins associated with the ACR bait were ubiquitinated. These proteins can be separated into four groups as follows: (a) group 1, proteins of the ubiquitin-conjugating system; (b) group 2, presynaptic proteins; (c) group 3, other proteins implicated in AD; and (d) group 4, phosphorylation-dependent ACR interactors. PubMed:27325702

Appears in Networks:

p(HBP:"APP, ACR") increases p(HGNC:SYT1, pmod(Ub)) View Subject | View Object

As reported in Table 6, several brain-derived proteins associated with the ACR bait were ubiquitinated. These proteins can be separated into four groups as follows: (a) group 1, proteins of the ubiquitin-conjugating system; (b) group 2, presynaptic proteins; (c) group 3, other proteins implicated in AD; and (d) group 4, phosphorylation-dependent ACR interactors. PubMed:27325702

Appears in Networks:

p(HBP:"APP, ACR") increases p(HGNC:SYT2, pmod(Ub)) View Subject | View Object

As reported in Table 6, several brain-derived proteins associated with the ACR bait were ubiquitinated. These proteins can be separated into four groups as follows: (a) group 1, proteins of the ubiquitin-conjugating system; (b) group 2, presynaptic proteins; (c) group 3, other proteins implicated in AD; and (d) group 4, phosphorylation-dependent ACR interactors. PubMed:27325702

Appears in Networks:

p(HBP:"APP, ACR") increases p(HGNC:RAB14, pmod(Ub)) View Subject | View Object

As reported in Table 6, several brain-derived proteins associated with the ACR bait were ubiquitinated. These proteins can be separated into four groups as follows: (a) group 1, proteins of the ubiquitin-conjugating system; (b) group 2, presynaptic proteins; (c) group 3, other proteins implicated in AD; and (d) group 4, phosphorylation-dependent ACR interactors. PubMed:27325702

Appears in Networks:

p(HBP:"APP, ACR") increases p(HGNC:SNAP25, pmod(Ub)) View Subject | View Object

As reported in Table 6, several brain-derived proteins associated with the ACR bait were ubiquitinated. These proteins can be separated into four groups as follows: (a) group 1, proteins of the ubiquitin-conjugating system; (b) group 2, presynaptic proteins; (c) group 3, other proteins implicated in AD; and (d) group 4, phosphorylation-dependent ACR interactors. PubMed:27325702

Appears in Networks:

p(HBP:"APP, ACR") increases p(HGNC:SYN2, pmod(Ub)) View Subject | View Object

As reported in Table 6, several brain-derived proteins associated with the ACR bait were ubiquitinated. These proteins can be separated into four groups as follows: (a) group 1, proteins of the ubiquitin-conjugating system; (b) group 2, presynaptic proteins; (c) group 3, other proteins implicated in AD; and (d) group 4, phosphorylation-dependent ACR interactors. PubMed:27325702

Appears in Networks:

p(HBP:"APP, ACR") increases p(HGNC:SYN1, pmod(Ub)) View Subject | View Object

As reported in Table 6, several brain-derived proteins associated with the ACR bait were ubiquitinated. These proteins can be separated into four groups as follows: (a) group 1, proteins of the ubiquitin-conjugating system; (b) group 2, presynaptic proteins; (c) group 3, other proteins implicated in AD; and (d) group 4, phosphorylation-dependent ACR interactors. PubMed:27325702

Appears in Networks:

p(HBP:"APP, ACR") increases p(HGNC:RAB3A, pmod(Ub)) View Subject | View Object

As reported in Table 6, several brain-derived proteins associated with the ACR bait were ubiquitinated. These proteins can be separated into four groups as follows: (a) group 1, proteins of the ubiquitin-conjugating system; (b) group 2, presynaptic proteins; (c) group 3, other proteins implicated in AD; and (d) group 4, phosphorylation-dependent ACR interactors. PubMed:27325702

Appears in Networks:

p(HBP:"APP, ACR") increases p(HGNC:APOE, pmod(Ub)) View Subject | View Object

As reported in Table 6, several brain-derived proteins associated with the ACR bait were ubiquitinated. These proteins can be separated into four groups as follows: (a) group 1, proteins of the ubiquitin-conjugating system; (b) group 2, presynaptic proteins; (c) group 3, other proteins implicated in AD; and (d) group 4, phosphorylation-dependent ACR interactors. PubMed:27325702

Appears in Networks:

p(HBP:"APP, ACR") increases p(HGNC:MAPT, pmod(Ub)) View Subject | View Object

As reported in Table 6, several brain-derived proteins associated with the ACR bait were ubiquitinated. These proteins can be separated into four groups as follows: (a) group 1, proteins of the ubiquitin-conjugating system; (b) group 2, presynaptic proteins; (c) group 3, other proteins implicated in AD; and (d) group 4, phosphorylation-dependent ACR interactors. PubMed:27325702

Appears in Networks:

p(HBP:"APP, ACR") regulates complex(GO:"ubiquitin ligase complex") View Subject | View Object

Together with the evidence that CRBN and CUL4B are linked to intellectual disability suggests a pathogenic mechanism, in which APP acts as a modulator of E3 ubiquitin-protein ligase(s). PubMed:27325702

Appears in Networks:

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.