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complex(g(MIRBASE:"rno-mir-195"), p(FPLX:NFkappaB))

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Components

Appears in Networks 1

Tau Modifications v1.9.5

Tau Modifications Sections of NESTOR

In-Edges 1

p(FPLX:NFkappaB) increases complex(g(MIRBASE:"rno-mir-195"), p(FPLX:NFkappaB)) View Subject | View Object

Chronic Brain hypoperfusion (CBH) elevates nuclear factor-kB (NF-kB), which binds with the promoter sequences of miR-195 and negatively regulates its expression. Down-regulated miR-195 up-regulates APP and BACE1 and increases Aß levels. Some Aß then enter the intracellular space and activate calpain, promoting the conversion of Cdk5/p35 to Cdk5/p25 and catalyzes the degradation of IkB (inhibitor of NF-?B)and directly phosphorylates Tau. Down-regulated miR-195 up-regulates p35, which provides the active substrates of p25 PubMed:26118667

Appears in Networks:

Out-Edges 3

complex(g(MIRBASE:"rno-mir-195"), p(FPLX:NFkappaB)) hasComponent g(MIRBASE:"rno-mir-195") View Subject | View Object

Appears in Networks:

complex(g(MIRBASE:"rno-mir-195"), p(FPLX:NFkappaB)) hasComponent p(FPLX:NFkappaB) View Subject | View Object

Appears in Networks:

complex(g(MIRBASE:"rno-mir-195"), p(FPLX:NFkappaB)) decreases m(MIRBASE:"rno-mir-195") View Subject | View Object

Chronic Brain hypoperfusion (CBH) elevates nuclear factor-kB (NF-kB), which binds with the promoter sequences of miR-195 and negatively regulates its expression. Down-regulated miR-195 up-regulates APP and BACE1 and increases Aß levels. Some Aß then enter the intracellular space and activate calpain, promoting the conversion of Cdk5/p35 to Cdk5/p25 and catalyzes the degradation of IkB (inhibitor of NF-?B)and directly phosphorylates Tau. Down-regulated miR-195 up-regulates p35, which provides the active substrates of p25 PubMed:26118667

Appears in Networks:

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.