path(MESH:"Disseminated Intravascular Coagulation")
However, 6 years later, Heyes and co-workers demonstrated in an experimental study in rats that infusions of thrombin induce DIC accompanied with hemolysis and schistocytosis [89]. PubMed:29956069
Recently, using a rat model of lipopolysaccharide (LPS)-induced systemic inflammation, our own collaboration could show that argatroban (a specific direct thrombin inhibitor and consequently an inhibitor of coagulation) abolishes DIC, schistocyte formation, and hemolysis. PubMed:29956069
Interestingly, inhibition of coagulation is capable of diminishing DIC and hemolysis but not antiplatelet therapy—treatment with eptifibatide (an antiplatelet drug of the glycoprotein IIb/IIIa inhibitor class) failed to reduce LPS-induced DIC, schistocyte formation, and hemolysis. PubMed:29956069
Surprisingly, 66% (187/282) of ABO incompatible transfusions are asymptomatic; however, 67% (19/282) result in death and 27% (76/282) in major morbidities (Bolton-Maggs et al, 2014), including DIC (Goldfinger, 1977). PubMed:25307023
Essential for the development of DIC during sepsis is the so-called pro-coagulatory shift of the endothelial cells, caused among others by an increased expression of tissue factor and adhesion molecules especially by damaged endothelial cells [87]. PubMed:29956069
Essential for the development of DIC during sepsis is the so-called pro-coagulatory shift of the endothelial cells, caused among others by an increased expression of tissue factor and adhesion molecules especially by damaged endothelial cells [87]. PubMed:29956069
During HUS, endothelial lesions cause a complement dependent activation of immune response and local thrombus formation—attachment of fibrin and platelets to the endothelial lesions and consequently disseminated intravascular coagulation (DIC)—and further mechanical destruction of the red blood cells in the fibrin mesh resulting in hemolysis [82]. PubMed:29956069
They concluded that intravascular coagulation must be the most likely cause of this microangiopathic hemolytic anemia. PubMed:29956069
Although haemolysis and thrombosis are hallmarks of the thrombo microangiopathies, such as disseminated intravascular coagulation (DIC) and thrombotic thrombocytopenic purpura/haemolytic uraemic syndrome (TTP/HUS), it is difficult to isolate the causative role of haemolysis in the pathophysiology of thrombosis in these complex disorders. PubMed:25307023
It is crucial, hence, to further investigate the mechanisms of sepsis-induced hemolysis with the aim of deriving possible therapeutic principles. Herein, we collected the most important previously known triggers of hemolysis during sepsis, which are (1) transfusion reactions and complement activation, (2) disseminated intravascular coagulation, (3) capillary stopped-flow, (4) restriction of glucose to red blood cells, (5) changes in red blood cell membrane properties, (6) hemolytic pathogens, and (7) red blood cell apoptosis. PubMed:29956069
Sepsis/systemic inflammation is frequently associated with disseminated intravascular coagulation (DIC) being a predictor of mortality in septic patients [84, 85]. PubMed:29956069
DIC is characterized by a systemic intravascular coagulation, formation of microvascular thrombi, insufficiently compensated consumption of platelets and coagulation factors, and eventually bleeding tendency [84]. PubMed:29956069
Although haemolysis and thrombosis are hallmarks of the thrombo microangiopathies, such as disseminated intravascular coagulation (DIC) and thrombotic thrombocytopenic purpura/haemolytic uraemic syndrome (TTP/HUS), it is difficult to isolate the causative role of haemolysis in the pathophysiology of thrombosis in these complex disorders. PubMed:25307023
DIC is characterized by a systemic intravascular coagulation, formation of microvascular thrombi, insufficiently compensated consumption of platelets and coagulation factors, and eventually bleeding tendency [84]. PubMed:29956069
Although haemolysis and thrombosis are hallmarks of the thrombo microangiopathies, such as disseminated intravascular coagulation (DIC) and thrombotic thrombocytopenic purpura/haemolytic uraemic syndrome (TTP/HUS), it is difficult to isolate the causative role of haemolysis in the pathophysiology of thrombosis in these complex disorders. PubMed:25307023
It is crucial, hence, to further investigate the mechanisms of sepsis-induced hemolysis with the aim of deriving possible therapeutic principles. Herein, we collected the most important previously known triggers of hemolysis during sepsis, which are (1) transfusion reactions and complement activation, (2) disseminated intravascular coagulation, (3) capillary stopped-flow, (4) restriction of glucose to red blood cells, (5) changes in red blood cell membrane properties, (6) hemolytic pathogens, and (7) red blood cell apoptosis. PubMed:29956069
Although haemolysis and thrombosis are hallmarks of the thrombo microangiopathies, such as disseminated intravascular coagulation (DIC) and thrombotic thrombocytopenic purpura/haemolytic uraemic syndrome (TTP/HUS), it is difficult to isolate the causative role of haemolysis in the pathophysiology of thrombosis in these complex disorders. PubMed:25307023
DIC is characterized by a systemic intravascular coagulation, formation of microvascular thrombi, insufficiently compensated consumption of platelets and coagulation factors, and eventually bleeding tendency [84]. PubMed:29956069
Surprisingly, 66% (187/282) of ABO incompatible transfusions are asymptomatic; however, 67% (19/282) result in death and 27% (76/282) in major morbidities (Bolton-Maggs et al, 2014), including DIC (Goldfinger, 1977). PubMed:25307023
Sepsis/systemic inflammation is frequently associated with disseminated intravascular coagulation (DIC) being a predictor of mortality in septic patients [84, 85]. PubMed:29956069
DIC is characterized by a systemic intravascular coagulation, formation of microvascular thrombi, insufficiently compensated consumption of platelets and coagulation factors, and eventually bleeding tendency [84]. PubMed:29956069
They concluded that intravascular coagulation must be the most likely cause of this microangiopathic hemolytic anemia. PubMed:29956069
However, 6 years later, Heyes and co-workers demonstrated in an experimental study in rats that infusions of thrombin induce DIC accompanied with hemolysis and schistocytosis [89]. PubMed:29956069
BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.
If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.