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p(HBP:"N-terminal fragment of ATF6")

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
N-terminal fragment of ATF6
Namespace
HBP
Namespace Version
20190207
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/cf4d8bb88754f036b943b4d94ad96e103dcb7149/export/hbp-names.belns

Appears in Networks 1

The Biology of Proteostasis in Aging and Disease v1.0.0

In-Edges 3

tloc(p(HBP:"N-terminal fragment of ATF6"), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus")) increases act(p(HBP:"N-terminal fragment of ATF6"), ma(tscript)) View Subject | View Object

The cytosolic N-terminal fragment of ATF6 that is generated translocates to the nucleus, binds DNA, and drives expression of a complementary set of UPR genes (8). PubMed:25784053

Appears in Networks:

p(HGNC:PRSS1) increases p(HBP:"N-terminal fragment of ATF6") View Subject | View Object

In parallel, ER stress promotes the relocation of ATF6 from the ER membrane to the Golgi apparatus, where it is cleaved by SP1 and SP2 proteases. PubMed:25784053

Appears in Networks:
Annotations
MeSH
Golgi Apparatus

p(HGNC:PRSS2) increases p(HBP:"N-terminal fragment of ATF6") View Subject | View Object

In parallel, ER stress promotes the relocation of ATF6 from the ER membrane to the Golgi apparatus, where it is cleaved by SP1 and SP2 proteases. PubMed:25784053

Appears in Networks:
Annotations
MeSH
Golgi Apparatus

Out-Edges 2

tloc(p(HBP:"N-terminal fragment of ATF6"), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus")) increases act(p(HBP:"N-terminal fragment of ATF6"), ma(tscript)) View Subject | View Object

The cytosolic N-terminal fragment of ATF6 that is generated translocates to the nucleus, binds DNA, and drives expression of a complementary set of UPR genes (8). PubMed:25784053

Appears in Networks:

act(p(HBP:"N-terminal fragment of ATF6"), ma(tscript)) increases bp(GO:"response to misfolded protein") View Subject | View Object

The cytosolic N-terminal fragment of ATF6 that is generated translocates to the nucleus, binds DNA, and drives expression of a complementary set of UPR genes (8). PubMed:25784053

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.