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complex(a(HBP:"kappa-Bungarotoxin"), p(HBP:"alpha-3 beta-4 nAChR"))

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albuquerque2009 v1.0.0

This file encodes the article Mammalian Nicotinic Acetylcholine Receptors: From Structure to Function by Albuquerque et al, 2009

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complex(a(HBP:"kappa-Bungarotoxin"), p(HBP:"alpha-3 beta-4 nAChR")) hasComponent a(HBP:"kappa-Bungarotoxin") View Subject | View Object

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complex(a(HBP:"kappa-Bungarotoxin"), p(HBP:"alpha-3 beta-4 nAChR")) hasComponent p(HBP:"alpha-3 beta-4 nAChR") View Subject | View Object

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complex(a(HBP:"kappa-Bungarotoxin"), p(HBP:"alpha-3 beta-4 nAChR")) decreases act(p(HBP:"alpha-3 beta-4 nAChR")) View Subject | View Object

Such toxins are not limited to the muscle receptor as seen in the Taiwanese krate snake. This snake produces “neuronal bungarotoxin” (also referred to as 3.1 toxin or kappa-bungarotoxin; Ref. 286), which preferentially binds to and inactivates neuronal nAChRs that contain the alpha3 and beta4 subunits. In this case, the specificity of the toxin appears to in part be controlled by the subtype of beta nAChR subunit; beta2-containing nAChRs are less sensitive than beta4-containing nAChRs to inhibition by neuronal BGT. PubMed:19126755

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.