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p(HGNC:NAIP)

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
NAIP
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 2

Activation and regulation of the inflammasomes v1.0.0

The role of inflammasome in Alzheimer’s disease v1.0.3

In-Edges 0

Out-Edges 2

act(p(HGNC:NAIP)) increases complex(GO:"IPAF inflammasome complex") View Subject | View Object

In mice, NAIP (NLR family, apoptosis inhibitory protein) family proteins sense the proteinaceous NLRC4 activators and, in turn, activate the assembly of the NLRC4 inflammasome. PubMed:23702978

Appears in Networks:
Annotations
Confidence
High

p(HGNC:NAIP) increases act(complex(GO:"IPAF inflammasome complex")) View Subject | View Object

Under certain but not all conditions ASC (Martinon et al., 2009) or Naip5 (NLR family, apoptosis inhibitory protein 5) (Lightfield et al., 2011) is required for the activity of the NLRC4 inflammasome PubMed:24561250

Appears in Networks:
Annotations
Confidence
High
NeuroMMSigDB
Caspase subgraph

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.