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complex(a(CHEBI:heme), p(MGI:Hpx))

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Components

Appears in Networks 1

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 1

a(CHEBI:heme) decreases complex(a(CHEBI:heme), p(MGI:Hpx)) View Subject | View Object

In a time-line experiment, we showed that heme loading of macrophages decreased the expression of heme–hemopexin complex receptor and transferrin receptor 1 (TfR1) (Fig. 4D), while ferritin levels remained largely unchanged except for an increase in ferritin levels at 16 h post-treatment (Fig. 4D). PubMed:29212341

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
Text Location
Results

Out-Edges 8

complex(a(CHEBI:heme), p(MGI:Hpx)) hasComponent a(CHEBI:heme) View Subject | View Object

Appears in Networks:

complex(a(CHEBI:heme), p(MGI:Hpx)) hasComponent p(MGI:Hpx) View Subject | View Object

Appears in Networks:

complex(a(CHEBI:heme), p(MGI:Hpx)) decreases p(MGI:Tgfb1) View Subject | View Object

We therefore next analyzed heme-Hx-treated wild-type mice that showed decreased hepatic expression of collagens, TGFβ, PDGF, SMA, and the tissue inhibitor of MMPs, TIMP2, as well as increased expression of the M2 polarizing colony stimulating factor-1 and MMPs compared with heme-HSA–treated mice ( Figure 7C). PubMed:26675351

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Liver
MeSH
Anemia, Sickle Cell
Text Location
Results

complex(a(CHEBI:heme), p(MGI:Hpx)) decreases p(PFAM:PDGF) View Subject | View Object

We therefore next analyzed heme-Hx-treated wild-type mice that showed decreased hepatic expression of collagens, TGFβ, PDGF, SMA, and the tissue inhibitor of MMPs, TIMP2, as well as increased expression of the M2 polarizing colony stimulating factor-1 and MMPs compared with heme-HSA–treated mice ( Figure 7C). PubMed:26675351

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Liver
MeSH
Anemia, Sickle Cell
Text Location
Results

complex(a(CHEBI:heme), p(MGI:Hpx)) decreases p(MGI:Acta2) View Subject | View Object

We therefore next analyzed heme-Hx-treated wild-type mice that showed decreased hepatic expression of collagens, TGFβ, PDGF, SMA, and the tissue inhibitor of MMPs, TIMP2, as well as increased expression of the M2 polarizing colony stimulating factor-1 and MMPs compared with heme-HSA–treated mice ( Figure 7C). PubMed:26675351

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Liver
MeSH
Anemia, Sickle Cell
Text Location
Results

complex(a(CHEBI:heme), p(MGI:Hpx)) decreases p(MGI:Timp2) View Subject | View Object

We therefore next analyzed heme-Hx-treated wild-type mice that showed decreased hepatic expression of collagens, TGFβ, PDGF, SMA, and the tissue inhibitor of MMPs, TIMP2, as well as increased expression of the M2 polarizing colony stimulating factor-1 and MMPs compared with heme-HSA–treated mice ( Figure 7C). PubMed:26675351

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Liver
MeSH
Anemia, Sickle Cell
Text Location
Results

complex(a(CHEBI:heme), p(MGI:Hpx)) increases p(MGI:Csf1) View Subject | View Object

We therefore next analyzed heme-Hx-treated wild-type mice that showed decreased hepatic expression of collagens, TGFβ, PDGF, SMA, and the tissue inhibitor of MMPs, TIMP2, as well as increased expression of the M2 polarizing colony stimulating factor-1 and MMPs compared with heme-HSA–treated mice ( Figure 7C). PubMed:26675351

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Liver
MeSH
Anemia, Sickle Cell
Text Location
Results

complex(a(CHEBI:heme), p(MGI:Hpx)) increases p(INTERPRO:"Peptidase M10A") View Subject | View Object

We therefore next analyzed heme-Hx-treated wild-type mice that showed decreased hepatic expression of collagens, TGFβ, PDGF, SMA, and the tissue inhibitor of MMPs, TIMP2, as well as increased expression of the M2 polarizing colony stimulating factor-1 and MMPs compared with heme-HSA–treated mice ( Figure 7C). PubMed:26675351

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Liver
MeSH
Anemia, Sickle Cell
Text Location
Results

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.