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composite(complex(GO:"filamentous actin"), p(HGNC:CFL1))

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Multivalent cross-linking of actin filaments and microtubules through the microtubule-associated protein Tau v1.0.0

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Out-Edges 3

composite(complex(GO:"filamentous actin"), p(HGNC:CFL1)) hasComponent complex(GO:"filamentous actin") View Subject | View Object

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composite(complex(GO:"filamentous actin"), p(HGNC:CFL1)) decreases complex(GO:"filamentous actin") View Subject | View Object

One of these binding partners is cofilin, a 21 kDa eukaryotic protein, which binds to F-actin with a Kd < 0.05 μM33 and results in disassembly of F-actin34, 35. Cryo-electron microscopy further showed that the binding site of cofilin on F-actin is highly similar to its binding site on G-actin (Fig. 2a)32 PubMed:29215007

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composite(complex(GO:"filamentous actin"), p(HGNC:CFL1)) hasComponent p(HGNC:CFL1) View Subject | View Object

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About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.