p(HGNC:MAPT)
to a(MESH:Neurons)
the application of extracellular tau increases the electrical activity of iPSC-derived or primary cortical neurons
p(HGNC:MAPT, loc(GO:"extracellular region")) increases act(a(MESH:Neurons))
32d7d94cf1
Moreover, extracellular tau may elicit cellular toxicity under certain conditions.
p(HGNC:MAPT, loc(GO:"extracellular region")) decreases a(MESH:Neurons)
1f203596b7
this observation suggests that the activity-dependent release of tau participates in a positive feedback loop on neuronal activity.
p(HGNC:MAPT) increases act(a(MESH:Neurons))
db5aa4735f
These studies indicate that the endogenous tau plays a part in regulating neuronal activity
p(HGNC:MAPT) regulates act(a(MESH:Neurons))
33315314a8
Intraneuronal iron accumulation, neuronal loss in the substantia nigra and a severe decline in locomotor functions were observed in 12‑month-old tau-knockoutmice
p(HGNC:MAPT) increases a(MESH:Neurons)
d271439061
Although tau function can be partly compensated by other, redundant microtubule-associated proteins (for example, MAP1A), the behavioural impairments observed in aged (~12‑month-old) tau-knockout mice indicate that tau is necessary for normal neuronal and brain function.
p(HGNC:MAPT) increases act(a(MESH:Neurons))
da4ebc0573
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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.