bp(GO:"necroptotic process")
Heme-induced necroptosis is reversed by deferoxamine, a Fe chelator. PubMed:24904418
mROS scavenger (Mito-TEMPO) and NADPH oxidases inhibitors (apocynin and DPI) block heme-induced necroptosis. PubMed:24904418
mROS scavenger (Mito-TEMPO) and NADPH oxidases inhibitors (apocynin and DPI) block heme-induced necroptosis. PubMed:24904418
mROS scavenger (Mito-TEMPO) and NADPH oxidases inhibitors (apocynin and DPI) block heme-induced necroptosis. PubMed:24904418
WhileMAPK8 increases ROS generation, TNF induces RIP1–RIP3 necrosome which triggers necroptosis. PubMed:24904418
Moreover, HO-1 has a protective effect during heme-induced necroptosis. PubMed:24904418
Therefore, it is clear that heme triggers ROS-induced sensitization of macrophages to TNFR-mediated cell death through RIP1 and RIP3 activation to promote necroptosis (Figure 2). PubMed:24904418
Moreover, HO-1 has a protective effect during heme-induced necroptosis. PubMed:24904418
WhileMAPK8 increases ROS generation, TNF induces RIP1–RIP3 necrosome which triggers necroptosis. PubMed:24904418
On the other hand, TNF secretion induced by heme is essential for the activation of the programed necrotic cell death pathway, which is denominated necroptosis (Fortes et al., 2012). PubMed:24904418
Heme-induced necroptosis is reversed by deferoxamine, a Fe chelator. PubMed:24904418
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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.