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complex(p(HGNC:APP), p(HGNC:SLC40A1))

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Components

Appears in Networks 1

Tau in physiology and pathology v1.0.0

In-Edges 1

surf(p(HGNC:APP)) increases complex(p(HGNC:APP), p(HGNC:SLC40A1)) View Subject | View Object

This study revealed that tau deficiency can cause iron accumulation inside neurons by preventing the trafficking of APP to the cell surface, where APP usually interacts with ferroportin (FPN) to facilitate the export of iron PubMed:26631930

Appears in Networks:
Annotations
MeSH
Neurons

Out-Edges 3

complex(p(HGNC:APP), p(HGNC:SLC40A1)) hasComponent p(HGNC:APP) View Subject | View Object

Appears in Networks:

complex(p(HGNC:APP), p(HGNC:SLC40A1)) hasComponent p(HGNC:SLC40A1) View Subject | View Object

Appears in Networks:

complex(p(HGNC:APP), p(HGNC:SLC40A1)) increases sec(a(CHEBI:"iron(0)")) View Subject | View Object

This study revealed that tau deficiency can cause iron accumulation inside neurons by preventing the trafficking of APP to the cell surface, where APP usually interacts with ferroportin (FPN) to facilitate the export of iron PubMed:26631930

Appears in Networks:
Annotations
MeSH
Neurons

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.