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a(MESH:Monocytes)

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Entity

Name
Monocytes
Namespace
mesh
Namespace Version
20180828
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/1b20f0637c395f8aa89c2e2e342d7b704062c242/external/mesh-names.belns

Appears in Networks 3

Functional aspects of meningeal lymphatics in ageing and Alzheimer’s disease v1.0.0

Clearance of Amyloid Beta and Tau in Alzheimer’s Disease:from Mechanisms to Therapy v1.0.1

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 4

p(HGNC:AMBP) positiveCorrelation a(MESH:Monocytes) View Subject | View Object

However, A1M treatment resulted in a transient increase in the total number of platelets 48 hours after the first injection and peripheral white blood cells, monocytes and lymphocytes 24 hours after the first injection. PubMed:24489717

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Kidney Tubules, Proximal
Text Location
Results

p(HGNC:IL15) positiveCorrelation a(MESH:Monocytes) View Subject | View Object

For example, monocytes from SCD patients show an enhanced state of activation, with increased expression of interleukin (IL)-15 and production of TNFα and IL-1β. PubMed:26675351

Appears in Networks:
Annotations
MeSH
Anemia, Sickle Cell
Text Location
Introduction

p(HGNC:IL1B) positiveCorrelation a(MESH:Monocytes) View Subject | View Object

For example, monocytes from SCD patients show an enhanced state of activation, with increased expression of interleukin (IL)-15 and production of TNFα and IL-1β. PubMed:26675351

Appears in Networks:
Annotations
MeSH
Anemia, Sickle Cell
Text Location
Introduction

p(HGNC:TNF) positiveCorrelation a(MESH:Monocytes) View Subject | View Object

For example, monocytes from SCD patients show an enhanced state of activation, with increased expression of interleukin (IL)-15 and production of TNFα and IL-1β. PubMed:26675351

Appears in Networks:
Annotations
MeSH
Anemia, Sickle Cell
Text Location
Introduction

Out-Edges 7

a(MESH:Monocytes) regulates deg(a(CHEBI:"amyloid-beta")) View Subject | View Object

By contrast, the parenchyma of the CNS is devoid of lymphatic vasculature2; in the brain, removal of cellular debris and toxic molecules, such as amyloid-β peptides, is mediated by a combination of transcellular transport mechanisms across the blood−brain and blood−cerebrospinal fluid (CSF) barriers7–9, phagocytosis and digestion by resident microglia and recruited monocytes and/or macrophages10,11, as well as CSF influx and ISF efflux through a paravascular (glymphatic) route12–14 PubMed:30046111

Appears in Networks:
Annotations
Confidence
High
MeSH
Brain

a(MESH:Monocytes) increases deg(a(CHEBI:"amyloid-beta")) View Subject | View Object

Aβ in periphery is mainly cleared by blood components, such as red cells (RBCs) and monocytes, or some tissues and organs, such as the liver and kidney (Fig. 2) PubMed:29626319

Appears in Networks:

a(MESH:Monocytes) increases deg(a(CHEBI:"amyloid-beta")) View Subject | View Object

Monocytes in peripheral blood have been demonstrated to play an important role in clearing Aβ that diffuses from brain to blood (Halle et al. 2015) PubMed:29626319

Appears in Networks:

a(MESH:Monocytes) positiveCorrelation p(HGNC:AMBP) View Subject | View Object

However, A1M treatment resulted in a transient increase in the total number of platelets 48 hours after the first injection and peripheral white blood cells, monocytes and lymphocytes 24 hours after the first injection. PubMed:24489717

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Kidney Tubules, Proximal
Text Location
Results

a(MESH:Monocytes) positiveCorrelation p(HGNC:IL15) View Subject | View Object

For example, monocytes from SCD patients show an enhanced state of activation, with increased expression of interleukin (IL)-15 and production of TNFα and IL-1β. PubMed:26675351

Appears in Networks:
Annotations
MeSH
Anemia, Sickle Cell
Text Location
Introduction

a(MESH:Monocytes) positiveCorrelation p(HGNC:TNF) View Subject | View Object

For example, monocytes from SCD patients show an enhanced state of activation, with increased expression of interleukin (IL)-15 and production of TNFα and IL-1β. PubMed:26675351

Appears in Networks:
Annotations
MeSH
Anemia, Sickle Cell
Text Location
Introduction

a(MESH:Monocytes) positiveCorrelation p(HGNC:IL1B) View Subject | View Object

For example, monocytes from SCD patients show an enhanced state of activation, with increased expression of interleukin (IL)-15 and production of TNFα and IL-1β. PubMed:26675351

Appears in Networks:
Annotations
MeSH
Anemia, Sickle Cell
Text Location
Introduction

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.