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p(HGNC:SRSF2)

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Entity

Name
SRSF2
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 2

Tau Modifications v1.9.5

Tau Modifications Sections of NESTOR

Tau in physiology and pathology v1.0.0

In-Edges 3

p(HGNC:SRSF2, pmod(Ac, Lys, 52)) positiveCorrelation act(p(HGNC:SRSF2)) View Subject | View Object

We found that SIRT1 interacts with and deacetylates SC35, and inhibits SC35-promoted tau exon 10 inclusion. Substituting K52 residue of SC35 by arginine impairs the role of SC35 in tau exon 10 inclusion. These results suggest that SIRT1 may serve as a therapeutic target for tauopathy by regulating SC35-mediated tau exon 10 splicing. PubMed:29226865

Appears in Networks:

complex(GO:"mitochondrial respiratory chain complex I") decreases p(HGNC:SRSF2) View Subject | View Object

Finally, inhibition of mitochondrial complex I (for example, using annonacin or MPP+ (1‑methyl‑4‑phenylpyridinium)) upregulates expression of the splicing factor SRSF2, thus promoting expression of 4R tau in human neurons. PubMed:26631930

Appears in Networks:

path(MESH:"Supranuclear Palsy, Progressive") positiveCorrelation p(HGNC:SRSF2) View Subject | View Object

Intriguingly, SRSF2 levels are increased in the brains of individuals with PSP. PubMed:26631930

Appears in Networks:
Annotations
MeSH
Brain

Out-Edges 5

p(HGNC:SRSF2) hasVariant p(HGNC:SRSF2, pmod(Ac, Lys, 52)) View Subject | View Object

Appears in Networks:

act(p(HGNC:SRSF2)) positiveCorrelation p(HGNC:SRSF2, pmod(Ac, Lys, 52)) View Subject | View Object

We found that SIRT1 interacts with and deacetylates SC35, and inhibits SC35-promoted tau exon 10 inclusion. Substituting K52 residue of SC35 by arginine impairs the role of SC35 in tau exon 10 inclusion. These results suggest that SIRT1 may serve as a therapeutic target for tauopathy by regulating SC35-mediated tau exon 10 splicing. PubMed:29226865

Appears in Networks:

act(p(HGNC:SRSF2)) increases p(HBP:"4R tau") View Subject | View Object

We found that SIRT1 interacts with and deacetylates SC35, and inhibits SC35-promoted tau exon 10 inclusion. Substituting K52 residue of SC35 by arginine impairs the role of SC35 in tau exon 10 inclusion. These results suggest that SIRT1 may serve as a therapeutic target for tauopathy by regulating SC35-mediated tau exon 10 splicing. PubMed:29226865

Appears in Networks:

p(HGNC:SRSF2) increases p(HBP:"4R tau") View Subject | View Object

Finally, inhibition of mitochondrial complex I (for example, using annonacin or MPP+ (1‑methyl‑4‑phenylpyridinium)) upregulates expression of the splicing factor SRSF2, thus promoting expression of 4R tau in human neurons. PubMed:26631930

Appears in Networks:

p(HGNC:SRSF2) positiveCorrelation path(MESH:"Supranuclear Palsy, Progressive") View Subject | View Object

Intriguingly, SRSF2 levels are increased in the brains of individuals with PSP. PubMed:26631930

Appears in Networks:
Annotations
MeSH
Brain

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.