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p(HGNC:MAPT, pmod(Me, Lys))

Equivalencies: 0 | Classes: 0 | Children: 7 | Explore

Entity

Name
MAPT
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 2

Tau Modifications v1.9.5

Tau Modifications Sections of NESTOR

Tau in physiology and pathology v1.0.0

In-Edges 8

p(HGNC:MAPT) hasVariant p(HGNC:MAPT, pmod(Me, Lys)) View Subject | View Object

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p(HGNC:MAPT, pmod(Me, Lys, 190)) isA p(HGNC:MAPT, pmod(Me, Lys)) View Subject | View Object

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p(HGNC:MAPT, pmod(Me, Lys, 24)) isA p(HGNC:MAPT, pmod(Me, Lys)) View Subject | View Object

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p(HGNC:MAPT, pmod(Me, Lys, 259)) isA p(HGNC:MAPT, pmod(Me, Lys)) View Subject | View Object

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p(HGNC:MAPT, pmod(Me, Lys, 290)) isA p(HGNC:MAPT, pmod(Me, Lys)) View Subject | View Object

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p(HGNC:MAPT, pmod(Me, Lys, 353)) isA p(HGNC:MAPT, pmod(Me, Lys)) View Subject | View Object

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p(HGNC:MAPT, pmod(Me, Lys, 44)) isA p(HGNC:MAPT, pmod(Me, Lys)) View Subject | View Object

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p(HGNC:MAPT, pmod(Me, Lys, 67)) isA p(HGNC:MAPT, pmod(Me, Lys)) View Subject | View Object

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Out-Edges 2

p(HGNC:MAPT, pmod(Me, Lys)) decreases a(HBP:"Tau aggregates") View Subject | View Object

These data indicate that Lys methylation depressed the intrinsic aggregation propensity of tau, and did so in part by increasing the concentration of tau needed to support fibril formation. PubMed:24869773

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p(HGNC:MAPT, pmod(Me, Lys)) decreases a(HBP:"Tau aggregates") View Subject | View Object

Lysine methylation is another endogenous post-translational modification of tau in the human brain, and in vitro studies have shown that methylation of tau suppresses its aggregation PubMed:26631930

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About

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.