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p(FPLX:HSP90, pmod(Ph))

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
HSP90
Namespace
FPLX
Namespace Version
20180917
Namespace URL
https://raw.githubusercontent.com/sorgerlab/famplex/e8ae9926ff95266032cb74f77973c84939bffbeb/export/famplex.belns

Appears in Networks 1

Imbalances in the Hsp90 Chaperone Machinery: Implications for Tauopathies v1.0.0

In-Edges 2

bp(MESH:Aging) increases p(FPLX:HSP90, pmod(Ph)) View Subject | View Object

These PTMs increase with aging and can alter the ability of Hsp90 to function properly as well as change the ability of different co-chaperones to bind. PubMed:29311797

Appears in Networks:

p(FPLX:HSP90) hasVariant p(FPLX:HSP90, pmod(Ph)) View Subject | View Object

Appears in Networks:

Out-Edges 1

p(FPLX:HSP90, pmod(Ph)) decreases act(p(FPLX:HSP90)) View Subject | View Object

Phosphorylation of Hsp90 leads to reduced chaperoning ability and phosphorylation of specific tyrosine residues can affect the ability of Hsp90 to interact with distinct client proteins (Zhao et al., 2001; Mollapour and Neckers, 2012). PubMed:29311797

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.