3',5'-cyclic GMP

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name: 3',5'-cyclic GMP
Namespace: chebi
Namespace Version: 20180906
Namespace URL: https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/chebi-names.belns

Appears in Networks 1

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 1

a(CHEBI:"nitric oxide") increases a(CHEBI:"3',5'-cyclic GMP") View Subject | View Object

As such, it nitrosylates the haem-moiety of guanylate cyclase, thereby stimulating formation of cyclic guanine monophosphate (cGMP), which then initiates calcium-dependent vasodilation (Olson et al, 2004). PubMed:25307023

Appears in Networks:

Heme Curation v0.0.1-dev

Annotations

Cell Ontology (CL): erythrocyte
MeSH: Plasma
MeSH: Urine
MeSH: Anemia, Hemolytic, Autoimmune
Text Location: Review

Out-Edges 2

a(CHEBI:"3',5'-cyclic GMP") increases bp(GO:vasodilation) View Subject | View Object

Appears in Networks:

Heme Curation v0.0.1-dev

Annotations

Cell Ontology (CL): erythrocyte
MeSH: Plasma
MeSH: Urine
MeSH: Anemia, Hemolytic, Autoimmune
Text Location: Review

a(CHEBI:"3',5'-cyclic GMP") decreases bp(MESH:"Platelet Aggregation") View Subject | View Object

NO inhibits platelet aggregation mediated by guanylate cyclase activation with a subsequent rise in cGMP (Faint et al, 1991). PubMed:25307023

Appears in Networks:

Heme Curation v0.0.1-dev

Annotations

Cell Ontology (CL): macrophage
MeSH: Plasma
MeSH: Urine
MeSH: Anemia, Hemolytic, Autoimmune
Text Location: Review

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.