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  3. composite(a(HBP:"Tau antibody, TNT1"), a(HBP:TOC1), p(HGNC:MAPT, pmod(Ph), var("p.S422E")))

composite(a(HBP:"Tau antibody, TNT1"), a(HBP:TOC1), p(HGNC:MAPT, pmod(Ph), var("p.S422E")))

Appears in Networks 1

Pseudophosphorylation of tau at S422 enhances SDS-stable dimer formation and impairs both anterograde and retrograde fast axonal transport. v1.0.0

In-Edges 1

p(HGNC:MAPT, pmod(Ph)) increases composite(a(HBP:"Tau antibody, TNT1"), a(HBP:TOC1), p(HGNC:MAPT, pmod(Ph), var("p.S422E")), loc(MESH:Brain)) View Subject | View Object

Staining in fixed tissue sections confirmed several previous reports (Kanaan et al., 2016; Mufson et al., 2014; Patterson et al., 2011a) that pS422 (Fig. 7A) extensively colocalizes with TNT1 (Fig. 7B) and TOC1 (Fig. 7C) in both control and AD brains, despite the relatively sparse appearance of tau pathology in the temporal cortices of control cases (data not shown). PubMed:27373205

Appears in Networks:

Out-Edges 3

composite(a(HBP:"Tau antibody, TNT1"), a(HBP:TOC1), p(HGNC:MAPT, pmod(Ph), var("p.S422E"))) hasComponent a(HBP:"Tau antibody, TNT1") View Subject | View Object

Appears in Networks:

composite(a(HBP:"Tau antibody, TNT1"), a(HBP:TOC1), p(HGNC:MAPT, pmod(Ph), var("p.S422E"))) hasComponent a(HBP:TOC1) View Subject | View Object

Appears in Networks:

composite(a(HBP:"Tau antibody, TNT1"), a(HBP:TOC1), p(HGNC:MAPT, pmod(Ph), var("p.S422E"))) hasComponent p(HGNC:MAPT, pmod(Ph), var("p.S422E")) View Subject | View Object

Appears in Networks:

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BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.