bp(GO:proteolysis)
It appears that E3s play a key role in the ubiquitin-mediated proteolytic cascade since they serve as the specific substrate recognition factors of the system PubMed:14556719
Mutations in PS1 were shown to impair the acidification of lysosomes, which is necessary for activating the proteolytic enzymes in this compartment. Improper acidification and impaired proteolysis of substrates would compromise the autophagy system and result in the accumulation of AVs as described above. PubMed:24027553
It appears that E3s play a key role in the ubiquitin-mediated proteolytic cascade since they serve as the specific substrate recognition factors of the system PubMed:14556719
The proteolytic degradation is also a major pathway of Aβ clearance PubMed:29626319
With neurons profoundly relying on macroautophagy for clearance of toxic protein aggregates, impairment in the proteolytic systems ultimately results in progressive neuronal death, a common feature in several neurodegenerative diseases [27]. PubMed:29758300
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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.