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complex(a(HBP:"Tau oligomers"), p(HGNC:HSPA1A))

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Components

Appears in Networks 1

Tau oligomers and tau toxicity in neurodegenerative disease v1.0.0

Tau oligomers and tau toxicity in neurodegenerative disease by Ward et al., 2012

In-Edges 0

Out-Edges 4

complex(a(HBP:"Tau oligomers"), p(HGNC:HSPA1A)) hasComponent a(HBP:"Tau oligomers") View Subject | View Object

Appears in Networks:

complex(a(HBP:"Tau oligomers"), p(HGNC:HSPA1A)) hasComponent p(HGNC:HSPA1A) View Subject | View Object

Appears in Networks:

complex(a(HBP:"Tau oligomers"), p(HGNC:HSPA1A)) decreases bp(GO:"anterograde axonal protein transport") View Subject | View Object

We illustrate that Hsp70 preferentially binds to tau oligomers over filaments and prevents anterograde FAT inhibition observed with a mixture of both forms of aggregated tau PubMed:22817713

Appears in Networks:
Annotations
Confidence
High
MeSH
Intracellular Space

complex(a(HBP:"Tau oligomers"), p(HGNC:HSPA1A)) increases bp(GO:"anterograde axonal protein transport") View Subject | View Object

However, our data indicate that Hsp70 preferentially binds to oligomeric as opposed to fibrillar tau aggregates and prevents anterograde FAT inhibition [31] PubMed:22817713

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Intracellular Space

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BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.