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p(HGNC:TREM2, var("p.Arg47His"))

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
TREM2
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 1

Clearance of Amyloid Beta and Tau in Alzheimer’s Disease:from Mechanisms to Therapy v1.0.1

In-Edges 1

p(HGNC:TREM2) hasVariant p(HGNC:TREM2, var("p.Arg47His")) View Subject | View Object

Appears in Networks:

Out-Edges 2

p(HGNC:TREM2, var("p.Arg47His")) decreases act(a(MESH:Microglia)) View Subject | View Object

However, due to the presence of the R47H mutation in AD, TREM2 cannot effectively recognize the lipid ligands and then fails to activate microglia, which leads to Aβ deposition (Jiang et al. 2014a; Jiang et al. 2013) PubMed:29626319

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

p(HGNC:TREM2, var("p.Arg47His")) increases a(CHEBI:"amyloid-beta") View Subject | View Object

However, due to the presence of the R47H mutation in AD, TREM2 cannot effectively recognize the lipid ligands and then fails to activate microglia, which leads to Aβ deposition (Jiang et al. 2014a; Jiang et al. 2013) PubMed:29626319

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.