1. Catalog
  2. Nodes
  3. p(HGNC:MAPT, pmod(HBP:misfolding))

p(HGNC:MAPT, pmod(HBP:misfolding))

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
MAPT
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 2

Imbalances in the Hsp90 Chaperone Machinery: Implications for Tauopathies v1.0.0

Alzheimer’s disease and the autophagic-lysosomal system v1.0.0

In-Edges 3

p(HGNC:MAPT) hasVariant p(HGNC:MAPT, pmod(HBP:misfolding)) View Subject | View Object

Appears in Networks:

p(HGNC:STUB1) increases deg(p(HGNC:MAPT, pmod(HBP:misfolding))) View Subject | View Object

In tauopathic mice, CHIP regulates the removal of tau species that have undergone abnormal phosphorylation and folding (Dickey et al., 2007b). PubMed:29311797

Appears in Networks:
Annotations
MeSH
Cerebral Cortex

a(CHEBI:"methylene blue") decreases p(HGNC:MAPT, pmod(HBP:misfolding)) View Subject | View Object

Methylene blue, a contrast agent that can reduce tau misfolding, has also been shown to induce macroautophagy, as indicated by elevated Beclin 1 and LC3-II levels and reduced tau and p62 levels in organotypic neuronal cultures and a mouse model of FTD [159] PubMed:29758300

Appears in Networks:

Out-Edges 1

p(HGNC:MAPT, pmod(HBP:misfolding)) increases bp(GO:"cell death in response to oxidative stress") View Subject | View Object

p23 also plays an important role in preventing endoplasmic reticulum (ER) stress-induced cell death, which can be triggered by misfolded proteins, like tau (Rao et al., 2006; Abisambra et al., 2013). PubMed:29311797

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.