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a(HBP:"polyQ aggregates")

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Entity

Name
polyQ aggregates
Namespace
HBP
Namespace Version
20190222
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/cfd2ee89d1a71126da8b5f452544b7fe43be67e7/export/hbp-names.belns

Appears in Networks 1

Protein aggregation can inhibit clathrin-mediated endocytosis by chaperone competition v1.0.0

In-Edges 0

Out-Edges 2

a(HBP:"polyQ aggregates") decreases act(p(HGNC:DNAJB1)) View Subject | View Object

It has been proposed that such an imbalance may trigger the onset of many neurodegenerative diseases (10, 26), and recent studies report that polyglutamine (polyQ)-based aggregates can se- quester and inhibit the function of a low-abundance cochaper- one, Sis1p/DNAJB1, in protein degradation (27). PubMed:24706768

Appears in Networks:

a(HBP:"polyQ aggregates") decreases bp(GO:endocytosis) View Subject | View Object

Previous studies have shown that ag- gregation of expanded polyQ negatively affects endocytosis in yeast and in human HEK 293 cells (34). PubMed:24706768

Appears in Networks:
Annotations
Experimental Factor Ontology (EFO)
HEK293

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.